FOP is a rare genetic condition, described mainly in man and cats, characterized by progressive, painful debilitation and shortened lifespan. A 10-month-old neutered male Savannah cat was referred for progressive gait abnormalities and multifocal firm masses within the soft-tissues that were unresponsive to previous treatment. Diagnosis of FOP was based on histopathological evaluation of intralesional biopsies, which revealed osteo-cartilaginous metaplasia and fibrocellular proliferation with intralesional chondrogenesis and endochondral ossification. The cat was managed with 5 mg/kg BID enrofloxacin and hydrotherapy for 3 years until acute death. During that three-year period, the cat displayed consistent improvement in endurance, quality of life, and range of motion. Postmortem histopathology further confirmed the diagnosis of FOP via identification of intramuscular and intra-fascial ossification with lymphoplasmacytic infiltration, degeneration, and regeneration of adjacent myocytes. To the authors’ knowledge, this is the first report of long-term enrofloxacin treatment and hydrotherapy for the management of FOP in a cat, leading to improved mobility and survival time, and the first report of FOP in an exotic breed cat.

FOP 是一种罕见的遗传病，主要发生在人和猫身上，其特征是进行性、疼痛性虚弱和寿命缩短。一只 10 个月大的绝育雄性萨凡纳猫因进行性步态异常和对先前治疗无反应的软组织内多灶性硬质肿块被转诊。FOP 的诊断基于病灶内活检的组织病理学评估，结果显示骨软骨化生和纤维细胞增生，并伴有病灶内软骨形成和软骨内骨化。这只猫用 5 mg/kg BID 恩诺沙星和水疗进行了 3 年的管理，直到急性死亡。在那三年期间，这只猫在耐力、生活质量和运动范围方面表现出持续改善。死后组织病理学通过鉴定肌内和筋膜内骨化以及相邻肌细胞的淋巴浆细胞浸润、变性和再生，进一步证实了 FOP 的诊断。据作者所知，这是第一份关于长期恩诺沙星治疗和水疗治疗猫 FOP 的报告，从而改善了活动能力和存活时间，也是外来品种猫 FOP 的第一份报告。