Advancing X-ray Luminescence for Imaging, Biosensing, and Theragnostics,Accounts of Chemical Research

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Advancing X-ray Luminescence for Imaging, Biosensing, and Theragnostics
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2022-12-19 , DOI: 10.1021/acs.accounts.2c00517
Zhongzhu Hong ₁ , Zhaowei Chen ₁ , Qiushui Chen _{1,

2} , Huanghao Yang _{1,

2}

Affiliation

X-ray luminescence is an optical phenomenon in which chemical compounds known as scintillators can emit short-wavelength light upon the excitation of X-ray photons. Since X-rays exhibit well-recognized advantages of deep penetration toward tissues and a minimal autofluorescence background in biological samples, X-ray luminescence has been increasingly becoming a promising optical tool for tackling the challenges in the fields of imaging, biosensing, and theragnostics. In recent years, the emergence of nanocrystal scintillators have further expanded the application scenarios of X-ray luminescence, such as high-resolution X-ray imaging, autofluorescence-free detection of biomarkers, and noninvasive phototherapy in deep tissues. Meanwhile, X-ray luminescence holds great promise in breaking the depth dependency of deep-seated lesion treatment and achieving synergistic radiotherapy with phototherapy.

中文翻译：

推进用于成像、生物传感和治疗学的 X 射线发光

X 射线发光是一种光学现象，其中称为闪烁体的化合物可以在 X 射线光子激发时发出短波长光。由于 X 射线具有深入组织的公认优势和生物样品中最小的自发荧光背景，因此 X 射线发光越来越成为应对成像、生物传感和治疗学领域挑战的有前途的光学工具。近年来，纳米晶闪烁体的出现进一步拓展了X射线发光的应用场景，如高分辨率X射线成像、生物标志物的无自发荧光检测、深层组织无创光疗等。同时，

更新日期：2022-12-19

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