Objective To estimate the global burden of type 2 diabetes in adolescents and young adults (aged 15-39 years) from 1990 to 2019. Design Systematic analysis. Data source Global Burden of Disease Study 2019. Participants aged 15-39 years from 204 countries and territories, 1990-2019. Main outcomes measures Age standardised incidence rate, age standardised disability adjusted life years (DALY) rate, and age standardised mortality rate for type 2 diabetes in people aged 15-39 years from 1990 to 2019, and proportional DALY attributable to different risk factors. Results From 1990 to 2019, significant increases in age standardised incidence rate and age standardised DALY rate were found for type 2 diabetes in adolescents and young adults globally (P<0.001). Age standardised incidence rate (per 100 000 population) increased from 117.22 (95% confidence interval 117.07 to 117.36) in 1990 to 183.36 (183.21 to 183.51) in 2019, and age standardised DALY rate (per 100 000 population) increased from 106.34 (106.20 to 106.48) in 1990 to 149.61 (149.47 to 149.75) in 2019. The age standardised mortality rate (per 100 000 population) was modestly increased from 0.74 (0.72 to 0.75) in 1990 to 0.77 (0.76 to 0.78) in 2019. When grouped by countries with different sociodemographic indexes, countries with a low-middle and middle sociodemographic index had the highest age standardised incidence rate and age standardised DALY rate in 2019, whereas countries with a low sociodemographic index had the lowest age standardised incidence rate but the highest age standardised mortality rate. Women generally had higher mortality and DALY rates than men at ages <30 years, but differences between the sexes were reversed in those aged >30 years except in countries with a low sociodemographic index. The main attributable risk factor for DALY for early onset type 2 diabetes was high body mass index in all regions by sociodemographic index. The proportional contribution of other risk factors varied across regions, however, with higher proportions of ambient particulate air pollution and smoking in countries with a high sociodemographic index and higher proportions of household air pollution from solid fuels and diet low in fruit in countries with a low sociodemographic index. Conclusions Early onset type 2 diabetes is a growing global health problem in adolescents and young adults, especially in countries with a low-middle and middle sociodemographic index. A greater disease burden in women aged <30 years was found. Specific measures are needed in countries with different levels of socioeconomic development because of the variable attributable risk factors for type 2 diabetes in adolescents and young adults. Data used in the analyses can be obtained from the Global Health Data Exchange Global Burden of Disease Results Tool ().

中文翻译：

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1990-2019 年青少年和年轻人 2 型糖尿病的全球负担：2019 年全球疾病负担研究的系统分析

目的 估计 1990 年至 2019 年青少年和年轻人（15-39 岁）2 型糖尿病的全球负担。设计系统分析。数据来源 2019 年全球疾病负担研究。来自 204 个国家和地区的 15-39 岁的参与者，1990-2019 年。主要结局指标为 1990 年至 2019 年 15-39 岁人群 2 型糖尿病的年龄标准化发病率、年龄标准化残疾调整生命年 (DALY) 率和年龄标准化死亡率，以及归因于不同风险因素的比例 DALY。结果 1990-2019年，全球青少年2型糖尿病年龄标准化发病率和年龄标准化DALY率显着升高（P<0.001）。年龄标准化发病率（每 10 万人）从 117 上升。1990 年的 22（95% 置信区间 117.07 到 117.36）到 2019 年的 183.36（183.21 到 183.51），年龄标准化 DALY 率（每 10 万人）从 1990 年的 106.34（106.20 到 106.48）增加到 149.67（149.48）5 2019 年。年龄标准化死亡率（每 10 万人）从 1990 年的 0.74（0.72 至 0.75）小幅上升至 2019 年的 0.77（0.76 至 0.78）。按具有不同社会人口指数的国家分组时，低2019年，社会人口指数中等和中等国家的年龄标准化发病率和年龄标准化DALY率最高，而社会人口指数低的国家年龄标准化发病率最低，但年龄标准化死亡率最高。在 30 岁以下时，女性的死亡率和 DALY 率通常高于男性，但在 30 岁以上的人群中，性别差异发生逆转，社会人口指数较低的国家除外。早发 2 型糖尿病 DALY 的主要归因危险因素是所有地区的社会人口学指数高体重指数。然而，其他风险因素的比例贡献因地区而异，在社会人口指数高的国家，环境颗粒物空气污染和吸烟的比例较高，而在社会人口指数低的国家，固体燃料和低水果饮食造成的家庭空气污染比例较高。社会人口指数。结论 早发性 2 型糖尿病是青少年和年轻人日益严重的全球健康问题，尤其是在社会人口指数处于中低水平的国家。< 年龄女性的疾病负担更大 30年被发现。由于青少年和年轻人 2 型糖尿病的可归因危险因素各不相同，因此社会经济发展水平不同的国家需要采取具体措施。分析中使用的数据可以从全球卫生数据交换全球疾病负担结果工具（).