Self-Pumping Janus Hydrogel with Aligned Channels for Accelerating Diabetic Wound Healing,Macromolecular Rapid Communications

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Self-Pumping Janus Hydrogel with Aligned Channels for Accelerating Diabetic Wound Healing
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2022-12-02 , DOI: 10.1002/marc.202200814
Wu-Yi Xiao _{1,

2} , Xi Liu ₃ , Wenbo Wang _{1,

2} , Xiaobin Zhang _{1,

2} , Yuzhe Wang _{1,

2} , Jinze Lan _{1,

2} , Baoshi Fan ₄ , Lianxin Shi _{1,

2,

5} , Xizi Wan _{1,

2} , Shutao Wang _{1,

2}

Affiliation

Excessive exudate secreted from diabetic wounds often results in skin overhydration, severe infections, and secondary damage upon dressing changes. However, conventional wound dressings are difficult to synchronously realize the non-maceration of wound sites and rapid exudate transport due to their random porous structure. Herein, a self-pumping Janus hydrogel with aligned channels (JHA) composed of hydrophilic poly (ethylene glycol) diacrylate (PEGDA) hydrogel layer and hydrophobic polyurethane (PU)/graphene oxide (GO)/polytetrafluoroethylene (PTFE) layer is designed to rapidly export exudate and accelerate diabetic wound healing. In the design, the ice-templating process endows the hydrophilic hydrogel layer with superior liquid transport ability and mechanical strength due to the formation of aligned channel structure. The hydrophobic layer with controlled thickness functions as an effective barrier to prevent exudate from wetting the skin surface. Experiments in diabetic rat model show that JHA can significantly promote re-epithelialization and collagen deposition, shorten the inflammation phase, and accelerate wound healing. This unique JHA dressing may have great potential for real-life usage in clinical patients.

中文翻译：

具有对齐通道的自泵 Janus 水凝胶可加速糖尿病伤口愈合

糖尿病伤口分泌的过多渗出物通常会导致皮肤水分过多、严重感染和换药时的继发性损伤。然而，传统的伤口敷料由于其随机的多孔结构，难以同时实现伤口部位的不浸渍和渗出液的快速输送。在此，设计了一种由亲水性聚（乙二醇）二丙烯酸酯（PEGDA）水凝胶层和疏水性聚氨酯（PU）/氧化石墨烯（GO）/聚四氟乙烯（PTFE）层组成的具有对齐通道的自泵送Janus水凝胶（JHA）输出渗出液并加速糖尿病伤口愈合。在设计中，由于形成了对齐的通道结构，冰模板工艺赋予了亲水水凝胶层优异的液体传输能力和机械强度。厚度可控的疏水层可作为有效屏障，防止渗出液润湿皮肤表面。糖尿病大鼠模型实验表明，JHA能显着促进上皮再形成和胶原沉积，缩短炎症期，加速伤口愈合。这种独特的 JHA 敷料可能在临床患者的实际使用中具有巨大潜力。

更新日期：2022-12-02

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