Information related to the diverse and dynamic metabolite composition of the small intestine is crucial for the diagnosis and treatment of various diseases. However, our current understanding of the physiochemical dynamics of metabolic processes within the small intestine is limited due to the lack of in situ access to the intestinal environment. Here, we report a demonstration of a battery-free ingestible biosensing system for monitoring metabolites in the small intestine. As a proof of concept, we monitor the intestinal glucose dynamics on a porcine model. Battery-free operation is achieved through a self-powered glucose biofuel cell/biosensor integrated into a circuit that performs energy harvesting, biosensing, and wireless telemetry via a power-to-frequency conversion scheme using magnetic human body communication. Such long-term biochemical analysis could potentially provide critical information regarding the complex and dynamic small intestine metabolic profiles.

与小肠多样化和动态代谢物组成相关的信息对于各种疾病的诊断和治疗至关重要。然而，由于缺乏进入肠道环境的原位通道，我们目前对小肠内代谢过程的生理化学动力学的理解是有限的。在这里，我们报告了一个无电池可摄入生物传感系统的演示，用于监测小肠中的代谢物。作为概念证明，我们在猪模型上监测肠道葡萄糖动力学。无电池操作是通过集成到电路中的自供电葡萄糖生物燃料电池/生物传感器实现的，该电路通过使用磁性人体通信的功率到频率转换方案执行能量收集、生物传感和无线遥测。