The aim of this research was to prepare a bistratal nanocomplex with a high loading capacity (LC) and harsh environment stability for controlled release of curcumin (Cur) in gastrointestinal conditions. Whey protein isolate (WPI)/short linear glucan (SLG) core–shell nanoparticles were fabricated by self-assembly for the delivery of Cur. The results showed that Cur@WPI@SLG nanoparticles had a relatively high LC (12.89 %) and small particle size (89.4 nm). The nanocomplex remained relatively stable in extreme pH conditions (2–4 and 8–10), high temperatures (60–70 °C), and ionic strength (<400 mM). Core–shell nanostructures facilitated the sustained release of Cur in simulated gastrointestinal conditions. In addition, the nanocomplex had little cytotoxicity at high concentrations, yet significantly enhanced the DPPH scavenging activity and reducing power of Cur. This delivery system will significantly improve the sustained release effect of Cur and broaden the application of hydrophobic nutrients in foods.

本研究的目的是制备具有高负载能力 (LC) 和恶劣环境稳定性的双层纳米复合物，用于在胃肠道条件下控制释放姜黄素 (Cur)。乳清分离蛋白 (WPI)/短线性葡聚糖 (SLG) 核壳纳米颗粒通过自组装制备，用于递送 Cur。结果表明，Cur@WPI@SLG 纳米粒子具有相对较高的 LC（12.89%）和较小的粒径（89.4 nm）。纳米复合物在极端 pH 条件（2-4 和 8-10）、高温（60-70 °C）和离子强度（<400 mM）下保持相对稳定。核壳纳米结构促进了 Cur 在模拟胃肠道条件下的持续释放。此外，纳米复合物在高浓度下几乎没有细胞毒性，但显着增强了 Cur 的 DPPH 清除活性和还原能力。该递送系统将显着提高Cur的缓释效果，拓宽疏水性营养素在食品中的应用。