Polychlorinated biphenyls (PCBs) are persistent toxic, organic chemicals that tend to accumulate in the food chain. This study reports the rapid and selective extraction and determination of PCBs (PCB81, 153, 105, 126, and 157) in milk samples by a dispersive solid-phase extraction (DSPE) coupled with gas chromatography-tandem mass spectrometry (GC–MS/MS). An ionic liquid-molecularly imprinted porous resin (IL-MIPPR) as a DSPE adsorbent was synthesized from m-aminophenol, formaldehyde, and 2,2′-benzidinedisulfonic acid as the monomer, crosslinker, and virtual template, respectively. The IL-MIPPR had a fast mass transfer (1.0 min) and good selectivity (imprinting factors of 1.8–3.0). The IL-MIPPR − DSPE − GC–MS/MS method exhibited good linearity (R² ≥ 0.9995), the limit of detections (LODs) < 0.6 pg/g, and the recoveries ranged from 82.8 % to 106 % with relative standard deviations ≤ 6.6 %. This method is thus better than previously reported methods in terms of the LOD, the adsorbent dosage, and the extraction time.

多氯联苯 (PCB) 是一种持久性有毒有机化学品，往往会在食物链中积累。本研究报告了通过分散固相萃取 (DSPE) 结合气相色谱-串联质谱法 (GC-MS/多发性硬化症）。以间氨基苯酚、甲醛和 2,2'-联苯胺二磺酸分别为单体、交联剂和虚拟模板，合成了作为 DSPE 吸附剂的离子液体分子印迹多孔树脂 (IL-MIPPR) 。IL-MIPPR 具有快速传质（1.0 分钟）和良好的选择性（印记因子为 1.8–3.0）。IL-MIPPR − DSPE − GC–MS/MS 方法表现出良好的线性 (R ² ≥ 0.9995)，检测限 (LOD) < 0.6 pg/g，回收率范围为 82.8% 至 106%，相对标准偏差 ≤ 6.6%。因此，该方法在 LOD、吸附剂剂量和提取时间方面优于以前报道的方法。