Antioxidants, widely utilized in the food packaging field, have a risk of migrating into foodstuffs and eventually entering the human body. In this work, a novel method was established for green extraction and determination of antioxidants in food simulants migrated from plastic packaging materials. It was found that the antioxidants could be extracted directly from food simulants by in-situ formation of hydrophobic deep eutectic solvents with low toxic medium-chain fatty alcohols. Under the optimal conditions, the limit of detection was 0.15 to 0.25 µg/L, and the limit of quantification was 0.5 to 1.0 µg/L for the antioxidants. The extraction reaches equilibrium in 2 min. Importantly, butylated hydroxytoluene was detected in two types of the surveyed food contact materials. The established method shows high sensitivity, high enrichment factor, and strong anti-interference ability, and can be used for the separation and enrichment of ultra-trace antioxidants in foodstuffs.

广泛应用于食品包装领域的抗氧化剂有迁移到食品中并最终进入人体的风险。在这项工作中，建立了一种绿色提取和测定从塑料包装材料迁移的食品模拟物中抗氧化剂的新方法。结果发现，通过与低毒中链脂肪醇原位形成疏水性低共熔溶剂，可以直接从食品模拟物中提取抗氧化剂。在最佳条件下，抗氧化剂的检测限为0.15～0.25 µg/L，定量限为0.5～1.0 µg/L。萃取在 2 分钟内达到平衡。重要的是，在两种类型的调查食品接触材料中检测到丁基化羟基甲苯。建立的方法灵敏度高，富集因子高，