Preparative-Scale Biocatalytic Oxygenation of N-Heterocycles with a Lyophilized Peroxygenase Catalyst,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Preparative-Scale Biocatalytic Oxygenation of N-Heterocycles with a Lyophilized Peroxygenase Catalyst
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-12-01 , DOI: 10.1002/anie.202214759
Balázs Pogrányi ₁ , Tamara Mielke ₁ , Alba Díaz-Rodríguez ₂ , Jared Cartwright ₃ , William P Unsworth ₁ , Gideon Grogan ₁

Affiliation

A lyophilized preparation of an unspecific peroxygenase variant from Agrocybe aegerita (rAaeUPO-PaDa-I-H) is a highly effective catalyst for the oxygenation of a diverse range of N-heterocyclic compounds. Scalable, high yielding and enantioselective biocatalytic oxygenations have been developed, including 27 preparative examples (ca. 100 mg scale) across a wide range of substrates, including alkyl pyridines, bicyclic N-heterocycles and indoles.

中文翻译：

N-杂环与冻干过氧化酶催化剂的制备规模生物催化氧化

来自Agrocybe aegerita (r Aae UPO-PaDa-IH)的非特异性过氧化酶变体的冻干制剂是多种N -杂环化合物氧化的高效催化剂。已开发出可扩展、高产和对映选择性生物催化氧化，包括 27 个制备实例（约 100 毫克规模），适用于广泛的底物，包括烷基吡啶、双环 N-杂环和吲哚。

更新日期：2022-12-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11