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Preparative-Scale Biocatalytic Oxygenation of N-Heterocycles with a Lyophilized Peroxygenase Catalyst
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-12-01 , DOI: 10.1002/anie.202214759
Balázs Pogrányi 1 , Tamara Mielke 1 , Alba Díaz-Rodríguez 2 , Jared Cartwright 3 , William P Unsworth 1 , Gideon Grogan 1
Affiliation  

A lyophilized preparation of an unspecific peroxygenase variant from Agrocybe aegerita (rAaeUPO-PaDa-I-H) is a highly effective catalyst for the oxygenation of a diverse range of N-heterocyclic compounds. Scalable, high yielding and enantioselective biocatalytic oxygenations have been developed, including 27 preparative examples (ca. 100 mg scale) across a wide range of substrates, including alkyl pyridines, bicyclic N-heterocycles and indoles.

中文翻译:

N-杂环与冻干过氧化酶催化剂的制备规模生物催化氧化

来自Agrocybe aegerita (r Aae UPO-PaDa-IH)的非特异性过氧化酶变体的冻干制剂是多种N -杂环化合物氧化的高效催化剂。已开发出可扩展、高产和对映选择性生物催化氧化,包括 27 个制备实例(约 100 毫克规模),适用于广泛的底物,包括烷基吡啶、双环 N-杂环和吲
更新日期:2022-12-01
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