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Potent pan-group quorum sensing inhibitors in Staphylococcus aureus revealed by N-terminal tailoring of peptidomimetics
Chemical Communications ( IF 4.3 ) Pub Date : 2022-12-01 , DOI: 10.1039/d2cc05733f
Ke Zhao 1 , Joseph K Vasquez 1 , Helen E Blackwell 1
Affiliation  

Staphylococcus aureus uses small peptides to assess its population densisty (i.e., quorum sensing) and regulate virulence at high cell number. Here, we report the design and synthesis of peptidomimetics based on these native signals that strongly block this communication pathway in all four specificity groups of S. aureus.

中文翻译:

肽模拟物的 N 端剪裁揭示了金黄色葡萄球菌中有效的泛群群体感应抑制剂

金黄色葡萄球菌使用小肽来评估其种群密度(群体感应)并调节高细胞数的毒力。在这里,我们报告了基于这些天然信号的拟肽设计和合成,这些信号强烈阻断了金黄色葡萄球菌所有四个特异性组中的这种交流途径。
更新日期:2022-12-01
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