Pd-catalyzed cascade coupling reaction of cyclopropanols with N-allenyl-2-iodoanilines to construct 3-substituted indole derivatives,Organic Chemistry Frontiers

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Pd-catalyzed cascade coupling reaction of cyclopropanols with N-allenyl-2-iodoanilines to construct 3-substituted indole derivatives
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2022-11-30 , DOI: 10.1039/d2qo01618d
Zhi-Kai Liu ₁ , Jia-Hao Zeng ₁ , Zhuang-Ping Zhan ₁

Affiliation

We report herein a concise and useful method for the construction of 3-substituted indole derivatives via a palladium-catalyzed ring-opening coupling reaction of cyclopropanols with N-allenyl-2-iodoanilines. Various indoles bearing different functional groups have been synthesized in moderate to good yields. Furthermore, a gram-scale experiment and diverse transformation of the products showed a great potential utility of this method.

中文翻译：

Pd催化环丙醇与N-allenyl-2-iodoanilines级联反应构建3-取代吲哚衍生物

我们在此报告了一种通过钯催化的环丙醇与N -allenyl-2-iodoanilines的开环偶联反应构建 3-取代吲哚衍生物的简洁而有用的方法。已经合成了带有不同官能团的各种吲哚，收率适中。此外，克级实验和产品的多样化转化显示了该方法的巨大潜在效用。

更新日期：2022-12-02

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