Ultrasmall Gold-Coated Mesoporous Polydopamine Nanoprobe to Enhance Chemodynamic Therapy by Self-Supplying H2O2 and Photothermal Stimulation,ACS Applied Materials & Interfaces

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Ultrasmall Gold-Coated Mesoporous Polydopamine Nanoprobe to Enhance Chemodynamic Therapy by Self-Supplying H2O2 and Photothermal Stimulation
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-11-30 , DOI: 10.1021/acsami.2c14031
Zhaoyang Wang ₁ , Yuehua Shi ₁ , Yu Shi ₁ , Jiahe Zhang ₁ , Ran Hao ₁ , Gangwan Zhang ₁ , Leyong Zeng ₁

Affiliation

Tumor microenvironment (TME) responsive chemodynamic therapy (CDT) showed an important application in inhibiting tumor growth by producing the highly toxic hydroxyl radical (·OH), but insufficient hydrogen peroxide (H₂O₂) and overexpressed glutathione (GSH) limited its application. Herein, by integrating photothermal therapy (PTT) and CDT, a new kind of mesoporous polydopamine (MPDA)-based cascade-reaction nanoplatform (MPDA@AuNPs-Cu) was designed for enhanced antitumor therapy, in which ultrasmall gold nanoparticles (AuNPs) with glucose oxidase (GOx)-like activity were deposited on MPDA for providing H₂O₂, and Cu²⁺ was chelated for GSH-responsive Fenton-like reaction. It was demonstrated that the MPDA@AuNPs-Cu nanoprobe showed high photothermal conversion efficiency and excellent biocompatibility. Moreover, the MPDA@AuNPs-Cu nanoprobe exhibited strong ·OH generation because of H₂O₂ self-generation and photothermal stimulation. Importantly, compared with MPDA-Cu, MPDA@AuNPs-Cu exhibited enhanced in vitro and in vivo CDT/PTT performance, by which the tumor growth was completely inhibited, achieving TME-responsive antitumor efficacy.

中文翻译：

超小型镀金介孔聚多巴胺纳米探针通过自供 H2O2 和光热刺激增强化学动力学治疗

肿瘤微环境（TME）反应性化学动力学疗法（CDT）通过产生剧毒的羟基自由基（·OH）在抑制肿瘤生长方面显示出重要的应用，但过氧化氢（H ₂ O ₂）不足和谷胱甘肽（GSH）过表达限制了其应用. 在此，通过整合光热疗法（PTT）和CDT，设计了一种新型的基于介孔聚多巴胺（MPDA）的级联反应纳米平台（MPDA@AuNPs-Cu）用于增强抗肿瘤治疗，其中超小金纳米粒子（AuNPs）具有葡萄糖氧化酶 (GOx) 样活性沉积在 MPDA 上以提供 H ₂ O ₂和 Cu ²⁺被螯合用于 GSH 反应性 Fenton 样反应。结果表明，MPDA@AuNPs-Cu纳米探针显示出高光热转换效率和优异的生物相容性。此外，由于H ₂ O ₂自生成和光热刺激，MPDA@AuNPs-Cu 纳米探针表现出强烈的·OH 生成。重要的是，与 MPDA-Cu 相比，MPDA@AuNPs-Cu 表现出增强的体外和体内CDT/PTT 性能，从而完全抑制肿瘤生长，实现 TME 响应性抗肿瘤功效。

更新日期：2022-11-30

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