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Ultrasmall Gold-Coated Mesoporous Polydopamine Nanoprobe to Enhance Chemodynamic Therapy by Self-Supplying H2O2 and Photothermal Stimulation
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-11-30 , DOI: 10.1021/acsami.2c14031
Zhaoyang Wang 1 , Yuehua Shi 1 , Yu Shi 1 , Jiahe Zhang 1 , Ran Hao 1 , Gangwan Zhang 1 , Leyong Zeng 1
Affiliation  

Tumor microenvironment (TME) responsive chemodynamic therapy (CDT) showed an important application in inhibiting tumor growth by producing the highly toxic hydroxyl radical (·OH), but insufficient hydrogen peroxide (H2O2) and overexpressed glutathione (GSH) limited its application. Herein, by integrating photothermal therapy (PTT) and CDT, a new kind of mesoporous polydopamine (MPDA)-based cascade-reaction nanoplatform (MPDA@AuNPs-Cu) was designed for enhanced antitumor therapy, in which ultrasmall gold nanoparticles (AuNPs) with glucose oxidase (GOx)-like activity were deposited on MPDA for providing H2O2, and Cu2+ was chelated for GSH-responsive Fenton-like reaction. It was demonstrated that the MPDA@AuNPs-Cu nanoprobe showed high photothermal conversion efficiency and excellent biocompatibility. Moreover, the MPDA@AuNPs-Cu nanoprobe exhibited strong ·OH generation because of H2O2 self-generation and photothermal stimulation. Importantly, compared with MPDA-Cu, MPDA@AuNPs-Cu exhibited enhanced in vitro and in vivo CDT/PTT performance, by which the tumor growth was completely inhibited, achieving TME-responsive antitumor efficacy.

中文翻译:

超小型镀金介孔聚多巴胺纳米探针通过自供 H2O2 和光热刺激增强化学动力学治疗

肿瘤微环境(TME)反应性化学动力学疗法(CDT)通过产生剧毒的羟基自由基(·OH)在抑制肿瘤生长方面显示出重要的应用,但过氧化氢(H 2 O 2)不足和谷胱甘肽(GSH)过表达限制了其应用. 在此,通过整合光热疗法(PTT)和CDT,设计了一种新型的基于介孔聚多巴胺(MPDA)的级联反应纳米平台(MPDA@AuNPs-Cu)用于增强抗肿瘤治疗,其中超小金纳米粒子(AuNPs)具有葡萄糖氧化酶 (GOx) 样活性沉积在 MPDA 上以提供 H 2 O 2和 Cu 2+被螯合用于 GSH 反应性 Fenton 样反应。结果表明,MPDA@AuNPs-Cu纳米探针显示出高光热转换效率和优异的生物相容性。此外,由于H 2 O 2自生成和光热刺激,MPDA@AuNPs-Cu 纳米探针表现出强烈的·OH 生成。重要的是,与 MPDA-Cu 相比,MPDA@AuNPs-Cu 表现出增强的体外体内CDT/PTT 性能,从而完全抑制肿瘤生长,实现 TME 响应性抗肿瘤功效。
更新日期:2022-11-30
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