Chemical injuries to the eye are emergencies with limited acute treatment options other than prompt irrigation and can cause permanent vision loss. We developed a perfluorodecalin-based supersaturated oxygen emulsion (SSOE) to topically deliver high concentration of oxygen to the eye. SSOE is manufactured in hyperbaric conditions and stored in a ready-to-use canister. Upon dispensation, SSOE rapidly raises partial oxygen pressure 3 times over atmospheric level. SSOE is biocompatible with human corneal cells and safe on mouse eyes in vivo. A single topical application of SSOE to the eye after alkali injury significantly promotes corneal epithelial wound healing, decreases anterior chamber exudation, and reduces optical opacity and cataract formation in mice. SSOE treatment reduces intraocular hypoxia, cell death, leukocyte infiltration, production of inflammatory mediators, and hypoxia-inducible factor 1-alpha signaling, thus hastening recovery of normal tissue integrity during the wound healing process. Here, we show that SSOE is an effective topical therapeutic in the acute treatment of ocular chemical injuries.

眼睛化学损伤属于紧急情况，除了立即冲洗之外，急性治疗选择有限，并且可能导致永久性视力丧失。我们开发了一种基于全氟萘烷的过饱和氧乳液 (SSOE)，可局部向眼睛输送高浓度的氧气。 SSOE 在高压条件下制造并储存在即用型罐中。分配后，SSOE 迅速将氧分压升高至大气水平的 3 倍。 SSOE 与人角膜细胞具有生物相容性，并且在体内对小鼠眼睛是安全的。在碱损伤后的眼睛上单次局部使用 SSOE 可以显着促进角膜上皮伤口愈合，减少前房渗出，并减少小鼠的光学混浊和白内障形成。 SSOE 治疗可减少眼内缺氧、细胞死亡、白细胞浸润、炎症介质的产生和缺氧诱导因子 1-α 信号传导，从而加速伤口愈合过程中正常组织完整性的恢复。在这里，我们证明 SSOE 是一种有效的局部治疗方法，可用于急性眼部化学损伤的治疗。