Euphylonoids A (1) and B (2), two highly modified jatrophane diterpenoids, were isolated from Euphorbia hylonoma. 1 represents a new 9(10→18)-abeo-8,12-cyclojatrophane skeleton containing a cage-like 3,8-dioxatricyclo[5.1.2.0^4,9]decane core, while 2 is a 14(13→20)-abeo-8,12-cyclojatrophane featuring an unusual 17-oxatetracyclo[12.2.1.0^1,5.0^9,13]heptadecane framework. Their structural elucidation was completed by spectroscopic, chemical, computational, and single-crystal X-ray diffraction means. 2 significantly inhibited early adipogenesis in 3T3-L1 adipocytes via activating AMP-activated protein kinase signaling.

中文翻译：

---

Euphylonoids A 和 B，两种高度改性的麻风树烷二萜类化合物，来自大戟属植物，具有强效降脂活性

Euphylonoids A ( 1 ) 和 B ( 2 ) 是两种高度修饰的麻疯烷二萜类化合物，是从大戟中分离得到的。1代表一个新的 9(10→18)- abeo -8,12-cyclojatrophane 骨架包含笼状 3,8-dioxatricyclo[5.1.2.0 ^4,9 ]decane 核心，而2是 14(13→20) - abeo -8,12-cyclojatrophane 具有不寻常的 17-oxatetracyclo[12.2.1.0 ^1,5 .0 ^9,13 ]heptadecane 框架。它们的结构解析是通过光谱、化学、计算和单晶X射线衍射手段完成的。2个通过激活 AMP 激活的蛋白激酶信号显着抑制 3T3-L1 脂肪细胞的早期脂肪生成。