INTRODUCTION There are overlapping biological origins and behaviors associated with obsessive-compulsive symptoms (OCS) and cannabis use. There is also evidence that OCS and cannabis use are associated over time. Thus, we investigated polygenic predisposition for OCS as predictive of OCS and cannabis use from age 17 to 19. We hypothesized that greater genetic risk for OCS would predict both OCS and cannabis use. METHODS The current study used participants from the Project Alliance 1 study, a US-based sample, for whom genomic, OCS, and cannabis use data were available (n = 547). Polygenic risk scores (PRS) were formed via a meta-genome-wide association study on OCS and examined as a predictor of OCS and cannabis use at age 17 and 19. The sample was diverse (52.4% male; 45% European American, 30% African American, 14% multiracial, 5% Hispanic/Latino, 4% Asian American, and 2% other groups). Sensitivity analysis was performed by gender for European American and African American subsamples. RESULTS Across the whole sample, the greater polygenic risk for OCS was negatively associated with cannabis use at age 17 and positively associated with OCS at 19. Cannabis use at age 17 was positively associated with OCS at age 19. The association between polygenic risk for OCS and cannabis use at age 17 was replicated in European American males, whereas the association between cannabis use at age 17 and OCS at age 19 was replicated in African American males. CONCLUSIONS Cannabis use may exacerbate OCS through adolescence, and genetic predisposition for OCS may be associated with lower cannabis use in efforts to avoid exacerbation of OCS.

中文翻译：

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遗传对青春期强迫行为症状与大麻使用之间相互作用的影响。


简介 强迫症状 (OCS) 和大麻使用有重叠的生物学起源和行为。还有证据表明，OCS 和大麻的使用随着时间的推移而存在关联。因此，我们研究了 OCS 的多基因易感性，以预测 17 至 19 岁的 OCS 和大麻使用。我们假设 OCS 的遗传风险较大，可以预测 OCS 和大麻的使用。方法 目前的研究使用了来自 Project Alliance 1 研究的参与者，这是一个美国样本，可以获得他们的基因组、OCS 和大麻使用数据 (n = 547)。多基因风险评分 (PRS) 是通过 OCS 的全基因组关联研究形成的，并作为 17 岁和 19 岁 OCS 和大麻使用的预测因子进行检验。样本具有多样性（52.4% 为男性；45% 为欧洲裔美国人；30% 为欧洲裔美国人）。 % 非裔美国人、14% 多种族、5% 西班牙裔/拉丁裔、4% 亚裔美国人和 2% 其他群体）。对欧洲裔美国人和非洲裔美国人子样本按性别进行敏感性分析。结果 在整个样本中，较大的 OCS 多基因风险与 17 岁时使用大麻呈负相关，与 19 岁时使用大麻呈正相关。17 岁时使用大麻与 19 岁时 OCS 呈正相关。OCS 多基因风险之间的关联欧洲裔美国男性在 17 岁时吸食大麻，而非洲裔美国男性在 17 岁时吸食大麻与 19 岁时吸食大麻之间存在关联。结论 大麻的使用可能会在青春期加剧 OCS，OCS 的遗传易感性可能与为避免 OCS 恶化而减少大麻使用有关。