Hericium erinaceus mycelium-Derived Polysaccharide Alleviates Ulcerative Colitis and Modulates Gut Microbiota in Cynomolgus Monkeys,Molecular Nutrition & Food Research

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Hericium erinaceus mycelium-Derived Polysaccharide Alleviates Ulcerative Colitis and Modulates Gut Microbiota in Cynomolgus Monkeys
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-11-28 , DOI: 10.1002/mnfr.202200450
Zhengyu Ren _{1,

2} , Zhenzhen Xu ₁ , William Kwame Amakye ₁ , Wei Liu ₃ , Zikuan Zhao ₁ , Li Gao ₁ , Min Wang ₁ , Jiaoyan Ren _{1,

4}

Affiliation

Ulcerative colitis (UC) is rapidly increasing worldwide but prolong use of available corticosteroids treatment is associated with numerous adverse effects. There is the urgent need to develop novel therapeutic options. However, this requires the use of suitable disease models, but current models are generated with chemical agents mainly in rodents, which are unable to recapitulate the human occurrence. The aim of this study is to validate the occurrence of spontaneous UC in cynomolgus monkeys and explore the potential of Hericium erinaceus mycelium-derived polysaccharide in reversing UC pathologies.

中文翻译：

猴头菇菌丝体衍生的多糖减轻溃疡性结肠炎并调节食蟹猴的肠道微生物群

溃疡性结肠炎 (UC) 在世界范围内迅速增加，但长期使用可用的皮质类固醇治疗与许多不良反应有关。迫切需要开发新的治疗选择。然而，这需要使用合适的疾病模型，但目前的模型主要是在啮齿动物中使用化学试剂生成的，无法概括人类的发生情况。本研究的目的是验证自发性 UC 在食蟹猴中的发生，并探索猴头菇菌丝体衍生的多糖在逆转 UC 病变方面的潜力。

更新日期：2022-11-28

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