The main goal of research is to study ring-opening polymerization of L-lactide in the presence of multifunctional alcohols in order to determine the optimal conditions for synthesis of star-shaped molecules of a predetermined well-defined structure, which is necessary for fine adjustment of material properties for various biomedical applications. The degree of polymerization of 3-, 4- and 6-arm star-shaped poly(L-lactides) varied from 10 to 100 monomer units per arm. It was found that under the same conditions polymerization rate and rate of initiation of co-initiator's hydroxyl groups can vary significantly depending on the structure and concentration of the selected alcohol. To prove the absence of cyclic, linear and comet-like structures in synthesized star-shaped PLLA, a variety of instrumental methods were used including GPC with triple detection, ¹H NMR and MALDI. Study of properties and supramolecular structure of poly(L-lactides) using DSC and WAXS demonstrated that branching limits segmental mobility of the PLLA chains, especially for short arms, and hinders crystallization of star-shaped poly(L-lactides).

研究的主要目标是研究 L-丙交酯在多官能醇存在下的开环聚合，以确定合成具有预定明确结构的星形分子的最佳条件，这是微调所必需的各种生物医学应用的材料特性。3、4 和 6 臂星形聚（L-丙交酯）的聚合度在每臂 10 到 100 个单体单元之间变化。发现在相同条件下，聚合速率和共引发剂的羟基的引发速率可显着变化，这取决于所选醇的结构和浓度。为了证明合成的星形 PLLA 中不存在环状、线性和彗星状结构，¹ H NMR 和 MALDI。使用 DSC 和 WAXS 对聚（L-丙交酯）的性质和超分子结构的研究表明，支化限制了 PLLA 链的链段移动性，特别是对于短臂，并阻碍了星形聚（L-丙交酯）的结晶。