Pyrrolidine molecules are a significant class of synthetic and natural plant metabolites, which show the diversity of pharmacological activities. An extensive variety of synthetic pyrrolidine compounds with numerous derivatization like spirooxindole, thiazole, metal complexes, coumarin, etc have revealed significant anticancer activity. Pyrrolidine molecules are found not only as potential anticancer candidates but also retain the lowest side effects. Depending upon the diverse substitution patterns of the derivatives, these molecules have demonstrated an incredible ability to regulate the various targets to give excellent anti-proliferative activities. Taking these into consideration, efforts have been taken by the scientific fraternity to design and develop a potent anticancer scaffold with negligible side effects. In the present review, we cover the latest advancements in the synthesis of pyrrolidine molecules which have promising anticancer activity toward numerous cancer cell lines. Additionally, it also highlights the effectiveness of derivatives via elucidation of Structural-Activity-Relationship (SAR) which is discussed in detail.

吡咯烷分子是一类重要的合成和天然植物代谢物，具有多样性的药理活性。多种衍生化的合成吡咯烷化合物如螺吲哚、噻唑、金属配合物、香豆素等已显示出显着的抗癌活性。吡咯烷分子不仅被发现是潜在的抗癌候选者，而且还保留了最低的副作用。根据衍生物的不同取代模式，这些分子已表现出令人难以置信的调节各种靶标的能力，从而提供出色的抗增殖活性。考虑到这些，科学界一直在努力设计和开发一种副作用可以忽略不计的有效抗癌支架。在本综述中，我们介绍了吡咯烷分子合成的最新进展，这些分子对多种癌细胞系具有良好的抗癌活性。此外，它还通过详细讨论的结构-活动-关系（SAR）的阐明来强调衍生品的有效性。