Higher air temperature is associated with increased age-related morbidity and mortality. To date, short-term effects of air temperature on leukocyte telomere length have not been investigated in an adult population. We aimed to examine the short-term associations between air temperature and leukocyte telomere length in an adult population-based setting, including two independent cohorts. This population-based study involved 5864 participants from the KORA F3 (2004–2005) and F4 (2006–2008) cohort studies conducted in Augsburg, Germany. Leukocyte telomere length was assessed by a quantitative PCR-based method. We estimated air temperature at each participant′s residential address through a highly resolved spatiotemporal model. We conducted cohort-specific generalized additive models to explore the short-term effects of air temperature on leukocyte telomere length at lags 0–1, 2–6, 0–6, and 0–13 days separately and pooled the estimates by fixed-effects meta-analysis. Our study found that between individuals, an interquartile range (IQR) increase in daily air temperature was associated with shorter leukocyte telomere length at lags 0–1, 2–6, 0–6, and 0–13 days (%change: −2.96 [−4.46; −1.43], −2.79 [−4.49; −1.07], −4.18 [−6.08; −2.25], and −6.69 [−9.04; −4.27], respectively). This meta-analysis of two cohort studies showed that between individuals, higher daily air temperature was associated with shorter leukocyte telomere length.

中文翻译：

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较高的每日气温与较短的白细胞端粒长度相关：KORA F3 和 KORA F4

较高的气温与年龄相关的发病率和死亡率增加有关。迄今为止，尚未在成年人群中研究气温对白细胞端粒长度的短期影响。我们的目的是在基于成年人群的环境中检查气温和白细胞端粒长度之间的短期关联，包括两个独立的队列。这项基于人群的研究涉及在德国奥格斯堡进行的 KORA F3 (2004-2005) 和 F4 (2006-2008) 队列研究的 5864 名参与者。通过基于定量 PCR 的方法评估白细胞端粒长度。我们通过高度分辨的时空模型估计了每个参与者居住地址的气温。我们进行了队列特异性广义加性模型，分别在滞后 0-1、2-6、0-6 和 0-13 天探索气温对白细胞端粒长度的短期影响，并通过固定效应汇总估计值荟萃分析。我们的研究发现，在个体之间，每日气温的四分位距 (IQR) 增加与滞后 0–1、2–6、0–6 和 0–13 天的白细胞端粒长度缩短相关（变化百分比：-2.96 [−4.46；−1.43]，−2.79 [−4.49；−1.07]，−4.18 [−6.08；−2.25]，和−6.69 [−9.04；−4.27]。这项对两项队列研究的荟萃分析表明，在个体之间，较高的每日气温与较短的白细胞端粒长度相关。我们的研究发现，在个体之间，每日气温的四分位距 (IQR) 增加与滞后 0–1、2–6、0–6 和 0–13 天的白细胞端粒长度缩短相关（变化百分比：-2.96 [−4.46；−1.43]，−2.79 [−4.49；−1.07]，−4.18 [−6.08；−2.25]，和−6.69 [−9.04；−4.27]。这项对两项队列研究的荟萃分析表明，在个体之间，较高的每日气温与较短的白细胞端粒长度相关。我们的研究发现，在个体之间，每日气温的四分位距 (IQR) 增加与滞后 0-1、2-6、0-6 和 0-13 天的白细胞端粒长度缩短相关（变化百分比：-2.96 [−4.46；−1.43]，−2.79 [−4.49；−1.07]，−4.18 [−6.08；−2.25]，和−6.69 [−9.04；−4.27]。这项对两项队列研究的荟萃分析表明，在个体之间，较高的每日气温与较短的白细胞端粒长度相关。