Molecular machines, such as ATPases or motor proteins, couple the catalysis of a chemical reaction, most commonly hydrolysis of nucleotide triphosphates, to their conformational change. In essence, they continuously convert a chemical fuel to drive their motion. An outstanding goal of nanotechnology remains to synthesize a nanomachine with similar functions, precision, and speed. The field of DNA nanotechnology has given rise to the engineering precision required for such a device. Simultaneously, the field of systems chemistry developed fast chemical reaction cycles that convert fuel to change the function of molecules. In this work, we thus combined a chemical reaction cycle with the precision of DNA nanotechnology to yield kinetic control over the conformational state of a DNA hairpin. Future work on such systems will result in out-of-equilibrium DNA nanodevices with precise functions.

中文翻译：

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使用化学燃料反应循环调节 DNA 杂交

分子机器，如 ATP 酶或运动蛋白，将化学反应的催化作用（最常见的是三磷酸核苷酸的水解）与其构象变化结合起来。本质上，它们不断地转化化学燃料来驱动它们的运动。纳米技术的一个突出目标仍然是合成具有相似功能、精度和速度的纳米机器。DNA 纳米技术领域已经提高了这种设备所需的工程精度。同时，系统化学领域开发了快速化学反应循环，可将燃料转化为改变分子功能的方法。因此，在这项工作中，我们将化学反应循环与 DNA 纳米技术的精度相结合，以产生对 DNA 发夹构象状态的动力学控制。