A novel porphyrin-based magnetic covalent organic framework (PCOF) was first reported by using a facile synthetic procedure. The Fe₃O₄@NH₂@PCOF nanospheres were utilized to effectively extract personal care products in a wide polarity range (log K_ow values from 1.96 to 7.60). The successful magnetic solid-phase extraction (MSPE) of target analytes could be ascribed to the sufficient oxygen-, nitrogen- and phenyl-containing functional groups of the COF layer, which are demonstrated to be of good compatibility with pollutants exhibiting different polarities by using molecular dynamics simulations, independent gradient model analysis and various characterizations. The MSPE extraction efficiency was enhanced by optimizing key parameters. The findings indicated that the method had a wide linearity range (1–500 ng mL⁻¹ for parabens and UV filters) and low detection limits (0.4–0.9 ng mL⁻¹ for parabens and 0.2–0.6 ng mL⁻¹ for UV filters). The accuracy was reflected by recoveries ranging from 74% to 114%. Satisfactory intra- and inter-day precisions from 3.0% to 9.8% and 0.5%–9.1% were obtained. Overall, the proposed MSPE-HPLC method is accurate and reliable for identifying parabens as well as UV filters in wastewater and swimming pool water. The potential of the method for evaluating human exposure risk was unfolded.

一种基于卟啉的新型磁性共价有机骨架 (PCOF) 首次通过简单的合成程序被报道。Fe ₃ O ₄ @NH ₂ @PCOF 纳米球被用于有效提取宽极性范围内的个人护理产品（log K _ow值从 1.96 到 7.60）。目标分析物的成功磁性固相萃取 (MSPE) 可归因于 COF 层具有足够的含氧、含氮和苯基的官能团，通过使用证明它们与表现出不同极性的污染物具有良好的相容性分子动力学模拟、独立梯度模型分析和各种表征。通过优化关键参数提高了 MSPE 提取效率。结果表明，该方法具有宽线性范围（对羟基苯甲酸酯和紫外线过滤剂为 1–500 ng mL ^-1）和低检测限（对羟基苯甲酸酯为 0.4–0.9 ng mL ^-1，对羟基苯甲酸酯为 0.2–0.6 ng mL ^-1用于紫外线过滤器）。准确度反映在 74% 到 114% 的回收率上。获得了 3.0% 至 9.8% 和 0.5%–9.1% 的令人满意的日内和日间精密度。总体而言，所提出的 MSPE-HPLC 方法可准确可靠地鉴定废水和游泳池水中的对羟基苯甲酸酯以及紫外线过滤剂。评估人体暴露风险的方法的潜力得到了展现。