Impact of Charge Composition and Distribution on the Antibacterial Properties of Polypeptide Coatings,ACS Macro Letters

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Impact of Charge Composition and Distribution on the Antibacterial Properties of Polypeptide Coatings
ACS Macro Letters ( IF 5.1 ) Pub Date : 2022-11-28 , DOI: 10.1021/acsmacrolett.2c00620
Zhiwei Liu ₁ , Fangping Yang ₁ , Wenting Si ₁ , Ruizhong Xue ₁ , Xiaotang Chu ₁ , Xinyun Tian ₁ , Lichen Yin ₁ , Haoyu Tang ₁

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Inspired by the charge composition and distribution of proteins and peptides, we designed and prepared a series of brush polypeptides with positive and negative charges separately distributed in the side chains and the backbones. The brush polypeptides can self- or co-deposit on various substrates forming ultrathin and stable coatings. They showed potent bactericidal activity and antibiofilm property, outperforming conventional linear polypeptide coatings with randomly distributed positive and negative charges. Keeping the balance of positive/negative charges and increasing the numbers of positive/negative charges can further improve the antibacterial property of brush polypeptide coatings without sacrificing their biocompatibility.

中文翻译：

电荷组成和分布对多肽涂层抗菌性能的影响

受蛋白质和多肽的电荷组成和分布的启发，我们设计并制备了一系列正负电荷分别分布在侧链和主链上的刷状多肽。刷状多肽可以自沉积或共沉积在各种基材上，形成超薄且稳定的涂层。它们显示出强大的杀菌活性和抗生物膜特性，优于具有随机分布的正电荷和负电荷的传统线性多肽涂层。保持正/负电荷的平衡，增加正/负电荷的数量，可以在不牺牲生物相容性的情况下进一步提高刷状多肽涂层的抗菌性能。

更新日期：2022-11-28

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