Gene by Intervention (GxI) interaction studies examine how a person's genotype may moderate (i.e., increase or decrease benefit from) an intervention's impact, typically in the context of randomized controlled trials. This systematic review examines genetic moderation effects for psychosocial and behavioral interventions that are family-based or school-/individual-based with family components. Differential susceptibility was the most widely used theory. All studies demonstrated significant GxI effects, but the large numbers of interventions and the fragmentary information provided by different genes limits the generalizability of conclusions. Future research should develop stronger biobehavioral theories, designs, and methodologie for studying genes in the family context. The GxI effects reviewed deepen our understanding of genetic moderation effects in intervention studies, provide implications for research by indicating who may benefit more from an intervention, and further guide efforts to personalize intervention programs to include elements to which people with certain genetic characteristics are more sensitive.

中文翻译：

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以家庭为中心的干预措施（GxI 交互）影响的遗传调节：系统评价

基因干预 (GxI) 相互作用研究检查一个人的基因型如何调节（即增加或减少受益）干预的影响，通常是在随机对照试验的背景下。该系统评价检查了以家庭为基础或以学校/个人为基础的具有家庭成分的社会心理和行为干预的遗传调节效应. 差异敏感性是使用最广泛的理论。所有研究都证明了显着的 GxI 效应，但大量的干预措施和不同基因提供的零碎信息限制了结论的普遍性。未来的研究应该开发更强大的生物行为理论、设计和方法来研究家庭背景下的基因。审查的 GxI 效应加深了我们对干预研究中遗传调节效应的理解，通过指出谁可能从干预中受益更多来为研究提供启示，并进一步指导个性化干预计划的努力，以包括具有某些遗传特征的人更敏感的元素.