Neurons use local protein synthesis to support their morphological complexity, which requires independent control across multiple subcellular compartments up to the level of individual synapses. We identify a signaling pathway that regulates the local synthesis of proteins required to form excitatory synapses on parvalbumin-expressing (PV + ) interneurons in the mouse cerebral cortex. This process involves regulation of the TSC subunit 2 (Tsc2) by the Erb-B2 receptor tyrosine kinase 4 (ErbB4), which enables local control of messenger RNA {mRNA} translation in a cell type–specific and synapse type–specific manner. Ribosome-associated mRNA profiling reveals a molecular program of synaptic proteins downstream of ErbB4 signaling required to form excitatory inputs on PV + interneurons. Thus, specific connections use local protein synthesis to control synapse formation in the nervous system.

中文翻译：

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通过突触类型特异性控制局部蛋白质合成的皮质连接


神经元使用局部蛋白质合成来支持其形态复杂性，这需要跨多个亚细胞区室直至单个突触水平的独立控制。我们确定了一条信号通路，可调节小白蛋白表达（PV）上形成兴奋性突触所需的蛋白质的局部合成。 + ）小鼠大脑皮层的中间神经元。该过程涉及 Erb-B2 受体酪氨酸激酶 4 (ErbB4) 对 TSC 亚基 2 (Tsc2) 的调节，从而能够以细胞类型特异性和突触类型特异性的方式局部控制信使 RNA {mRNA} 翻译。核糖体相关 mRNA 分析揭示了在 PV 上形成兴奋性输入所需的 ErbB4 信号下游突触蛋白的分子程序+中间神经元。因此，特定连接利用局部蛋白质合成来控制神经系统中突触的形成。