Herein we report the synthesis of 3-aryl oxindoles having trifluoromethylated quaternary stereocenters through the catalyst free arylation of 3-trifluoromethyl,3-tosyloxy oxindoles with anisoles. The transformation proceeds via electrophilic 3-(trifluoromethyl)-2H-indolium intermediate (Michael acceptor), which is generated by the heterolytic cleavage of C-OTs bond under metal-free conditions in PEG-400. The developed strategy offers broad substrate scope, extending to N,N-dimethyl-anilines, and thio-anisole to afford the range of 3-trifluoromethyl,3-aryl oxindoles in 62–91% yields.

中文翻译：

---

无催化剂芳基化合成具有三氟甲基化季立体中心的 3-芳基羟吲哚

在此，我们报告了通过 3-三氟甲基，3-甲苯磺酰氧基羟吲哚与苯甲醚的无催化剂芳基化反应，合成了具有三氟甲基化季立体中心的 3-芳基羟吲哚。转化通过亲电子 3-(三氟甲基)-2 H-吲哚中间体（Michael 受体）进行，该中间体由 C-OTs 键在 PEG-400 中无金属条件下异裂解产生。开发的策略提供了广泛的底物范围，扩展到N,N-二甲基苯胺和硫代苯甲醚，以 62-91% 的收率提供 3-三氟甲基、3-芳基羟吲哚的范围。