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Caesalpinia palmeri: First Report on the Phenolic Compounds Profile, Antioxidant and Cytotoxicity Effect
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2022-11-24 , DOI: 10.1002/cbdv.202200631
J C López-Romero 1 , H Torres-Moreno 1 , M Vidal-Gutiérrez 2 , G G Cabrera-Cabrera 1 , R E Robles-Zepeda 3 , K L Rodríguez-Martínez 4 , J Ortega-García 1 , M A Villegas-Ochoa 5 , Norma J Salazar-López 6 , J Abraham Domínguez-Avila 7 , G A González-Aguilar 5
Affiliation  

This study aimed to determine the phenolic compounds profile, antioxidant potential and cytotoxicity of extracts and fractions of Caesalpinia palmeri. Methanolic extracts were generated from C. palmeri berries, stems and flowers. The latter was subjected to liquid-liquid partition, obtaining hexane, ethyl acetate and residues fractions. Results showed that the flower extract and ethyl acetate fraction had a larger concentration of phenolic compounds (148.9 and 307.9 mg GAE/g, respectively), being ellagic acid (6233.57 and 19550.08 μg/g, respectively), quercetin-3-β-glycoside (3023.85 and 8952.55 μg/g, respectively) and gallic acid (2212.98 and 8422.34 μg/g, respectively) the most abundant compounds. Flower extract and ethyl acetate fraction also presented the highest antioxidant capacity on all tested methods (DPPH, ABTS, ORAC and FRAP) and low cytotoxicity against ARPE-19 cells (IC50 >170 μg/mL). C. palmeri possessed high antioxidant potential, associated with the presence of phenolic compounds and low cytotoxicity, suggesting that they could represent an option to counter oxidative stress.

中文翻译:

棕榈云实:关于酚类化合物概况、抗氧化和细胞毒性作用的第一份报告

本研究旨在确定棕榈云实提取物和馏分的酚类化合物概况、抗氧化潜力和细胞毒性。甲醇提取物是从C. palmeri中产生的浆果、茎和花。后者进行液-液分配,得到己烷、乙酸乙酯和残余馏分。结果表明,花提取物和乙酸乙酯馏分中含有较高浓度的酚类化合物(分别为 148.9 和 307.9 mg GAE/g),即鞣花酸(分别为 6233.57 和 19550.08 μg/g)、槲皮素-3-β-糖苷(分别为 3023.85 和 8952.55 μg/g)和没食子酸(分别为 2212.98 和 8422.34 μg/g)含量最高的化合物。花提取物和乙酸乙酯组分在所有测试方法(DPPH、ABTS、ORAC 和 FRAP)中也表现出最高的抗氧化能力,并且对 ARPE-19 细胞的细胞毒性较低(IC 50 >170 μg/mL)。C. palmeri具有高抗氧化潜力,与酚类化合物的存在和低细胞毒性有关,表明它们可以代表对抗氧化应激的一种选择。
更新日期:2022-11-24
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