当前位置: X-MOL 学术J. Agric. Food Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Ceramides from Sea Red Rice Bran Improve Health Indicators and Increase Stress Resistance of Caenorhabditis elegans through Insulin/IGF-1 Signaling (IIS) Pathway and JNK-1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2022-11-23 , DOI: 10.1021/acs.jafc.2c04921
Gang Wang 1 , Bingbing Song 1 , Xuejing Jia 1 , Huan Yin 1 , Rui Li 1, 2 , Xiaofei Liu 1, 2 , Jianping Chen 1, 2 , Jieliang Zhang 1, 2 , Zhuo Wang 1, 2 , Saiyi Zhong 1, 2, 3
Affiliation  

The antiaging effects of sea red rice bran in vivo, a new saline-tolerant sea rice byproduct containing high levels of ceramides (Cers), remain unknown. This study aimed to explore the antiaging effects exerted by Cers from sea red rice bran on Caenorhabditis elegans, assess its health indicators as well as tolerance, and then reveal the mechanism of action of Cers in prolonging the mean life span through genetic studies. The results indicated that the mean life span of Cers-treated C. elegans were dose-dependent in the range of 0.10–0.50 mg/mL. Additionally, Cers improved nematode motility, reduced lipofuscin accumulation, and enhanced resistance to heat stress and antioxidant enzyme activity. Genetic studies showed that Cers treatment had altered nematode gene expression. In addition, insulin/IGF-1 and jnk-1/mitogen-activated protein kinase (MAPK) signaling pathways successfully demonstrated the longevity effects of Cers intake. In short, these results suggest that Cers enhance the resistance of C. elegans and prolong its life span.

中文翻译:

来自海红米糠的神经酰胺通过胰岛素/IGF-1 信号通路 (IIS) 和 JNK-1 改善健康指标并提高秀丽隐杆线虫的抗压能力

海红米糠一种新的耐盐海米副产品,含有高水平的神经酰胺 (Cers),其抗衰老作用尚不清楚。本研究旨在探索海红米糠中的Cers对秀丽隐杆线虫的抗衰老作用,评估其健康指标和耐受性,进而通过基因研究揭示Cers延长平均寿命的作用机制。结果表明,经 Cers 处理的秀丽隐杆线虫的平均寿命在 0.10–0.50 mg/mL 范围内呈剂量依赖性。此外,Cers 改善了线虫的运动能力,减少了脂褐素的积累,增强了对热应激和抗氧化酶活性的抵抗力。遗传学研究表明,Cers 处理改变了线虫基因表达。此外,胰岛素/IGF-1 和jnk-1 /丝裂原活化蛋白激酶 (MAPK) 信号通路成功证明了 Cers 摄入的长寿效应。简而言之,这些结果表明 Cers 增强了秀丽隐杆线虫的抵抗力并延长了其寿命。
更新日期:2022-11-23
down
wechat
bug