Direct synthesis of fluorene-based spirolactones through a BF3-promoted spiroannulation of α-keto acids and o-alkynylbiaryls,Organic Chemistry Frontiers

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Direct synthesis of fluorene-based spirolactones through a BF3-promoted spiroannulation of α-keto acids and o-alkynylbiaryls
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2022-11-24 , DOI: 10.1039/d2qo01523d
Qingting Song ₁ , Zhen Zhang ₁ , Xiaoyu Xie ₁ , Guang-Zhu Ding ₁ , Pinhua Li ₁ , Lei Wang _{1,

2,

3} , Tao Miao ₁

Affiliation

A novel and practical approach to substituted fluorene-based spirolactones has been described via an efficient BF₃-promoted spiroannulation of α-keto acids and o-alkynyl biaryls. This metal-free cascade reaction proceeds smoothly at room temperature, and provides a wide range of structurally diverse products in good to excellent yields under mild conditions.

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