Abstract

The aim of this study was to assess the possible association between P-Albumin and 30-day mortality in hip fracture patients. The study is based on information from a database of hip fracture patients, established and collected at Bispebjerg University Hospital (Copenhagen, Denmark). This database includes all femoral neck (DS720), pertrochanteric (DS721) and subtrochanteric fractures (DS722) admitted to Bispebjerg Hospital between 1996 and 2012. We further identified all surgically treated hip fracture patients aged >60 years with an available P-Albumin at admission. 1856 patients were eligible for inclusion in this study (73.7% female, 26.3% male). 11.8% of these had died within 30 days. Differences between continuous variables were tested using unpaired t-tests while differences in the distribution of categorical variables were tested using chi square tests. After adjusting for co-variates in a logistic regression model, the association between P-Albumin and 30-day mortality remained increased, (OR 1.09, 95% CI 1.05;1.11 (p < 0.0001)). This study shows an increased 30-day mortality risk among surgically treated hip fracture patients with decreasing levels of P-Albumin even after adjusting for age, sex, BMI, CCI and fracture type. Routine screening of patients for hypoalbuminemia at hospital admission may be beneficial in the management of hip fracture patients.

摘要

本研究的目的是评估 P-白蛋白与髋部骨折患者 30 天死亡率之间的可能关联。该研究基于在 Bispebjerg 大学医院（丹麦哥本哈根）建立和收集的髋部骨折患者数据库中的信息。该数据库包括 1996 年至 2012 年间在 Bispebjerg 医院收治的所有股骨颈 (DS720)、粗隆旁骨折 (DS721) 和粗隆下骨折 (DS722)。我们进一步确定了所有接受手术治疗的髋部骨折患者，年龄 >60 岁，入院时可用 P-白蛋白. 1856 名患者符合纳入本研究的条件（73.7% 女性，26.3% 男性）。其中 11.8% 在 30 天内死亡。使用未配对的t测试连续变量之间的差异- 测试，同时使用卡方检验测试分类变量分布的差异。在逻辑回归模型中调整协变量后，P-白蛋白与 30 天死亡率之间的关联仍然增加，(OR 1.09, 95% CI 1.05;1.11 ( p  < 0.0001))。这项研究表明，即使在调整了年龄、性别、BMI、CCI 和骨折类型后，经过手术治疗的髋部骨折患者的 30 天死亡率风险也会增加，而 P-白蛋白水平会降低。入院时对患者进行低白蛋白血症的常规筛查可能有益于髋部骨折患者的管理。