Innate and adaptive immune cells patrol and survey throughout the human body and sometimes reside in the tumor microenvironment (TME) with a variety of cell types and nutrients that may differ from those in which they developed. The metabolic pathways and metabolites of immune cells are rooted in cell physiology, and not only provide nutrients and energy for cell growth and survival but also influencing cell differentiation and effector functions. Nowadays, there is a growing awareness that metabolic processes occurring in cancer cells can affect immune cell function and lead to tumor immune evasion and angiogenesis. In order to safely treat cancer patients and prevent immune checkpoint blockade-induced toxicities and autoimmunity, we suggest using anti-angiogenic drugs solely or combined with Immune checkpoint blockers (ICBs) to boost the safety and effectiveness of cancer therapy. As a consequence, there is significant and escalating attention to discovering techniques that target metabolism as a new method of cancer therapy. In this review, a summary of immune-metabolic processes and their potential role in the stimulation of intracellular signaling in TME cells that lead to tumor angiogenesis, and therapeutic applications is provided.

中文翻译：

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肿瘤微环境细胞的代谢谱和细胞内信号通路在实体瘤血管生成中的作用

先天性和适应性免疫细胞在整个人体巡逻和调查，有时驻留在肿瘤微环境 (TME) 中，具有多种细胞类型和营养物质，这些细胞类型和营养物质可能与其发育时的细胞类型和营养物质不同。免疫细胞的代谢途径和代谢产物植根于细胞生理学，不仅为细胞生长和存活提供营养和能量，而且影响细胞分化和效应功能。如今，人们越来越意识到癌细胞中发生的代谢过程会影响免疫细胞功能并导致肿瘤免疫逃避和血管生成。为了安全地治疗癌症患者并预防免疫检查点阻断引起的毒性和自身免疫，我们建议单独使用抗血管生成药物或与免疫检查点阻滞剂 (ICB) 联合使用，以提高癌症治疗的安全性和有效性。因此，人们越来越关注发现以新陈代谢为靶标的技术作为一种新的癌症治疗方法。在这篇综述中，总结了免疫代谢过程及其在刺激 TME 细胞内导致肿瘤血管生成的细胞内信号传导中的潜在作用，并提供了治疗应用。