当前位置: X-MOL 学术J. Am. Chem. Soc. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Genetically Encoded Phosphine Ligand for Metalloprotein Design
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2022-11-23 , DOI: 10.1021/jacs.2c09683
Hua-Zhen Duan 1 , Cheng Hu 2 , Yue-Lin Li 1 , Shi-Hao Wang 1 , Yan Xia 2 , Xiaohong Liu 2 , Jiangyun Wang 2 , Yong-Xiang Chen 1
Affiliation  

Phosphine ligands are the most important class of ligands for cross-coupling reactions due to their unique electronic and steric properties. However, metalloproteins generally rely on nitrogen, sulfur, or oxygen ligands. Here, we report the genetic incorporation of P3BF, which contains a biocompatible borane-protected phosphine, into proteins. This step is followed by a straightforward one-pot strategy to perform deboronation and palladium coordination in aqueous and aerobic conditions. The genetically encoded phosphine ligand P3BF should significantly expand our ability to design functional metalloproteins.

中文翻译:

用于金属蛋白设计的基因编码膦配体

由于其独特的电子和空间特性,膦配体是交叉偶联反应中最重要的一类配体。然而,金属蛋白通常依赖于氮、硫或氧配体。在这里,我们报告了 P3BF 的基因掺入蛋白质中,其中含有生物相容性硼烷保护的膦。这一步之后是一个简单的一锅策略,在水和有氧条件下进行脱硼和钯配位。基因编码的膦配体 P3BF 应该会显着扩展我们设计功能性金属蛋白的能力。
更新日期:2022-11-23
down
wechat
bug