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Ameliorative Effects of Propolis and Royal Jelly against CCl4-Induced Hepatotoxicity and Nephrotoxicity in Wistar Rats
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2022-11-23 , DOI: 10.1002/cbdv.202200948 Muhamed Focak 1 , Damir Suljevic 1
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2022-11-23 , DOI: 10.1002/cbdv.202200948 Muhamed Focak 1 , Damir Suljevic 1
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Carbon tetrachloride (CCl4) is known to have hepatotoxic and nephrotoxic effects. During the two-month CCl4 exposure of Wistar rats, propolis extract (PE) and royal jelly (RJ) were added in order to test the potential protective effect against hepato-renal injury. Ketonuria, proteinuria, high creatinine and urea levels are the result of CCl4-induced nephrotoxicity. Severe disorders of hematological indicators indicate anemia; high values of leukocytes indicate inflammatory condition. Cytogenetic impairments in hepatocytes, aggregation of platelets, and hypoproteinemia indicate severe liver impairment. Results suggest a more significant protective role of RJ compared to PE. Both extracts regulated proteinuria, ketonuria, hypoproteinemia and reduced platelet aggregation in the hepatic circulation. The increase in the number of erythrocytes (RBC) suggest protective effects against anemia; the decrease in the number of leukocytes can be linked to anti-inflammatory effects. PE and RJ have a beneficial effect against hepato-renal injury, anemia and anti-inflammatory conditions caused by CCl4.
中文翻译：
蜂胶和蜂王浆对 CCl4 诱导的 Wistar 大鼠肝毒性和肾毒性的改善作用
已知四氯化碳 (CCl 4 ) 具有肝毒性和肾毒性作用。在 Wistar 大鼠两个月的 CCl 4暴露期间，添加蜂胶提取物（PE）和蜂王浆（RJ）以测试对肝肾损伤的潜在保护作用。酮尿、蛋白尿、高肌酐和尿素水平是 CCl 4的结果-诱导的肾毒性。血液学指标严重紊乱表明贫血；白细胞值高表明有炎症。肝细胞的细胞遗传学损伤、血小板聚集和低蛋白血症表明严重的肝损伤。结果表明，与 PE 相比，RJ 具有更显着的保护作用。两种提取物均可调节蛋白尿、酮尿、低蛋白血症并减少肝循环中的血小板聚集。红细胞 (RBC) 数量的增加表明对贫血有保护作用；白细胞数量的减少可能与抗炎作用有关。PE 和 RJ 对由 CCl 4引起的肝肾损伤、贫血和抗炎病症具有有益作用。
更新日期：2022-11-23
中文翻译：
蜂胶和蜂王浆对 CCl4 诱导的 Wistar 大鼠肝毒性和肾毒性的改善作用
已知四氯化碳 (CCl 4 ) 具有肝毒性和肾毒性作用。在 Wistar 大鼠两个月的 CCl 4暴露期间，添加蜂胶提取物（PE）和蜂王浆（RJ）以测试对肝肾损伤的潜在保护作用。酮尿、蛋白尿、高肌酐和尿素水平是 CCl 4的结果-诱导的肾毒性。血液学指标严重紊乱表明贫血；白细胞值高表明有炎症。肝细胞的细胞遗传学损伤、血小板聚集和低蛋白血症表明严重的肝损伤。结果表明，与 PE 相比，RJ 具有更显着的保护作用。两种提取物均可调节蛋白尿、酮尿、低蛋白血症并减少肝循环中的血小板聚集。红细胞 (RBC) 数量的增加表明对贫血有保护作用；白细胞数量的减少可能与抗炎作用有关。PE 和 RJ 对由 CCl 4引起的肝肾损伤、贫血和抗炎病症具有有益作用。
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