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Degradable Selenium-Containing Polymers for Low Cytotoxic Antibacterial Materials
ACS Macro Letters ( IF 5.1 ) Pub Date : 2022-11-22 , DOI: 10.1021/acsmacrolett.2c00537 Yingying Li 1 , Xiaoliang Ma 1 , Jiandong Zhang 1 , Xiangqiang Pan 1 , Na Li 1 , Gaojian Chen 1 , Jian Zhu 1
ACS Macro Letters ( IF 5.1 ) Pub Date : 2022-11-22 , DOI: 10.1021/acsmacrolett.2c00537 Yingying Li 1 , Xiaoliang Ma 1 , Jiandong Zhang 1 , Xiangqiang Pan 1 , Na Li 1 , Gaojian Chen 1 , Jian Zhu 1
Affiliation
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Developing biodegradable cationic polymers with high antibacterial efficiency and low cytotoxicity is of great significance in biological applications. Selenium is an essential trace element for the human body, and selenium-containing compounds are promising in various health-related applications. To combine selenium with biodegradability, selenide-functionalized polycaprolactones (PCL) with different hydrophobic substituents were synthesized followed by selenoniumization. The optimal polyselenonium salt showed excellent antibacterial activity with an MBC of 2 μg mL–1 and an MIC of 1 μg mL–1 and exhibited good biocompatibility before and after degradation. In addition, the obtained selenium polymer can be well blended with commercial PCL by electrospinning, and films with good antibacterial activity were prepared. This work enriches the knowledge of selenium derivatives and lays a foundation for follow-up research on selenium cationic polymers in the antimicrobial field.
中文翻译：
用于低细胞毒性抗菌材料的可降解含硒聚合物
开发具有高抗菌效率和低细胞毒性的可生物降解阳离子聚合物在生物应用中具有重要意义。硒是人体必需的微量元素，含硒化合物在各种与健康相关的应用中前景广阔。为了将硒与生物降解性结合起来，合成了具有不同疏水取代基的硒化物功能化聚己内酯 (PCL)，然后进行硒化。最佳聚硒盐表现出优异的抗菌活性，MBC 为 2 μg mL –1，MIC 为 1 μg mL –1降解前后均表现出良好的生物相容性。此外，所获得的硒聚合物可以通过静电纺丝与商用PCL很好地共混，制备出具有良好抗菌活性的薄膜。该工作丰富了硒衍生物的知识，为后续硒阳离子聚合物在抗菌领域的研究奠定了基础。
更新日期：2022-11-22
中文翻译：
用于低细胞毒性抗菌材料的可降解含硒聚合物
开发具有高抗菌效率和低细胞毒性的可生物降解阳离子聚合物在生物应用中具有重要意义。硒是人体必需的微量元素，含硒化合物在各种与健康相关的应用中前景广阔。为了将硒与生物降解性结合起来，合成了具有不同疏水取代基的硒化物功能化聚己内酯 (PCL)，然后进行硒化。最佳聚硒盐表现出优异的抗菌活性，MBC 为 2 μg mL –1，MIC 为 1 μg mL –1降解前后均表现出良好的生物相容性。此外，所获得的硒聚合物可以通过静电纺丝与商用PCL很好地共混，制备出具有良好抗菌活性的薄膜。该工作丰富了硒衍生物的知识，为后续硒阳离子聚合物在抗菌领域的研究奠定了基础。
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