Exploring visible light for carbon–nitrogen and carbon–oxygen bond formation via nickel catalysis,Organic Chemistry Frontiers

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Exploring visible light for carbon–nitrogen and carbon–oxygen bond formation via nickel catalysis
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2022-11-23 , DOI: 10.1039/d2qo01700h
Shengqing Zhu ₁ , Huan Li ₁ , Yingying Li ₁ , Zhonghou Huang ₁ , Lingling Chu ₁

Affiliation

Heteroatom-containing motifs are one of the most privileged scaffolds for pharmaceuticals, agrochemicals, and functional materials. Transition-metal-catalyzed carbon–heteroatom bond-forming reactions have emerged as an indispensable synthetic tool for the rapid assembly of these valuable skeletons. Despite impressive progress, the development of general and efficient methods for the catalytic construction of carbon–heteroatom bonds with Earth-abundant catalysts under mild conditions is still highly desirable. Utilizing the new and unique reactivity uncovered by photoexcitation, recently, exciting progress has been made in the area of visible-light-driven nickel-catalyzed carbon–heteroatom bond-forming reactions, enabling facile access to diverse carbon–heteroatom bonds under exceptionally mild conditions. In this review, we highlight the recent synthetic methodology development for the formation of C–N and C–O bonds via visible-light-driven high-valent nickel complexes or photoexcited nickel complexes, with in-depth discussions with reaction designs and mechanistic scenarios.

中文翻译：

探索可见光通过镍催化形成碳氮和碳氧键

含杂原子基序是药物、农用化学品和功能材料中最有优势的支架之一。过渡金属催化的碳-杂原子成键反应已成为快速组装这些有价值的骨架不可或缺的合成工具。尽管取得了令人瞩目的进展，但仍然非常需要开发在温和条件下与地球丰富的催化剂催化构建碳-杂原子键的通用且有效的方法。利用光激发发现的新的和独特的反应性，最近，在可见光驱动的镍催化碳-杂原子键形成反应领域取得了令人兴奋的进展，能够在异常温和的条件下轻松获得多种碳-杂原子键. 在这篇评论中，通过可见光驱动的高价镍络合物或光激发镍络合物，深入讨论反应设计和机械场景。

更新日期：2022-11-23

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