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Metalloporphyrin-Based Metal–Organic Framework Nanorods for Peroxidase-Like Catalysis
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2022-11-21 , DOI: 10.1021/acsanm.2c03871 Yijin Shu 1 , Qiao Ye 1 , Jingwen Tan 2 , Hui Lv 1 , Zhiyin Liu 1 , Qijie Mo 3
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2022-11-21 , DOI: 10.1021/acsanm.2c03871 Yijin Shu 1 , Qiao Ye 1 , Jingwen Tan 2 , Hui Lv 1 , Zhiyin Liu 1 , Qijie Mo 3
Affiliation
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Metal–organic frameworks (MOFs) and their derivatives are emerging biosensing platforms due to their rational structural optimization. Herein, several metalloporphyrin–Porous Coordinated Network-222 (M-PCN-222) are developed for composition-dependent hydrogen peroxide (H2O2) sensing. A typical colorimetric sensing method (via a 3,3′,5,5′-tetramethylbenzidine-induced allochroic reaction) is employed to investigate the intrinsic peroxidase activity of M-PCN-222 (M = Mn, Fe, Co, and Ni). Fe-PCN-222 affords high sensitivity, good selectivity, robust stability, and a widely applicable concentration range. Theoretical investigations of active sites reveal that such different performances stem from the OH* binding on the M-PCN-222 surface. In addition, the adsorption energy of OH* on Fe-PCN-222 is similar to that of natural horseradish peroxidase. Molecular dynamics simulations are performed on Fe-PCN-222 nanorods to study the catalytic process of H2O2 based on their abundant micropores and mesopores. The obtained results suggest that the porphyrinic Fe-PCN-222 nanorod-based colorimetric sensing of H2O2 has great potential in catalysis, biosensors, and food industries.
中文翻译：
用于类过氧化物酶催化的金属卟啉基金属有机骨架纳米棒
金属有机框架 (MOF) 及其衍生物由于其合理的结构优化而成为新兴的生物传感平台。在此，开发了几种金属卟啉-多孔配位网络-222 (M-PCN-222)，用于依赖于组成的过氧化氢 (H 2 O 2）感应。采用典型的比色传感方法（通过 3,3',5,5'-四甲基联苯胺诱导的变色反应）研究 M-PCN-222（M = Mn、Fe、Co 和 Ni）的内在过氧化物酶活性. Fe-PCN-222 具有高灵敏度、良好的选择性、稳健的稳定性和广泛的适用浓度范围。活性位点的理论研究表明，这种不同的性能源于 M-PCN-222 表面上的 OH* 结合。此外，Fe-PCN-222对OH*的吸附能与天然辣根过氧化物酶相似。对Fe-PCN-222纳米棒进行分子动力学模拟研究H 2 O 2的催化过程基于它们丰富的微孔和中孔。所得结果表明，基于卟啉Fe-PCN-222纳米棒的H 2 O 2比色传感在催化、生物传感器和食品工业中具有巨大潜力。
更新日期：2022-11-21
中文翻译：
用于类过氧化物酶催化的金属卟啉基金属有机骨架纳米棒
金属有机框架 (MOF) 及其衍生物由于其合理的结构优化而成为新兴的生物传感平台。在此，开发了几种金属卟啉-多孔配位网络-222 (M-PCN-222)，用于依赖于组成的过氧化氢 (H 2 O 2）感应。采用典型的比色传感方法（通过 3,3',5,5'-四甲基联苯胺诱导的变色反应）研究 M-PCN-222（M = Mn、Fe、Co 和 Ni）的内在过氧化物酶活性. Fe-PCN-222 具有高灵敏度、良好的选择性、稳健的稳定性和广泛的适用浓度范围。活性位点的理论研究表明，这种不同的性能源于 M-PCN-222 表面上的 OH* 结合。此外，Fe-PCN-222对OH*的吸附能与天然辣根过氧化物酶相似。对Fe-PCN-222纳米棒进行分子动力学模拟研究H 2 O 2的催化过程基于它们丰富的微孔和中孔。所得结果表明，基于卟啉Fe-PCN-222纳米棒的H 2 O 2比色传感在催化、生物传感器和食品工业中具有巨大潜力。
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