Silica nanoparticle remodeling under mild conditions: versatile one step conversion of mesoporous to hollow nanoparticles with simultaneous payload loading,Nanoscale

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Silica nanoparticle remodeling under mild conditions: versatile one step conversion of mesoporous to hollow nanoparticles with simultaneous payload loading
Nanoscale ( IF 5.8 ) Pub Date : 2022-11-21 , DOI: 10.1039/d2nr05528g
Cassandra C Shaffer ₁ , Canjia Zhai ₁ , Jordan L Chasteen ₁ , Tatyana Orlova ₂ , Maksym Zhukovskyi ₂ , Bradley D Smith ₁

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A binary mixture of mesoporous silica nanoparticles plus organic polyammonium additive (dye or drug) is cleanly converted upon mild heating into hollow nanoparticles. The remodeled nanoparticle shell is an organized nanoscale assembly of globular additive/silica subunits and cancer cell assays show that a loaded drug additive is bioavailable.

中文翻译：

温和条件下的二氧化硅纳米颗粒重塑：介孔纳米颗粒多功能一步转化为空心纳米颗粒，同时负载负载

介孔二氧化硅纳米粒子加有机聚铵添加剂（染料或药物）的二元混合物在温和加热后干净地转化为中空纳米粒子。重塑的纳米颗粒壳是球状添加剂/二氧化硅亚基的有组织的纳米级组装体，癌细胞分析表明负载的药物添加剂具有生物可利用性。

更新日期：2022-11-21

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