Ultrasound is effective to fabricate nanocomplex. Soymilk is a natural nanocarrier with good compatibility. However, information about soymilk-nutraceuticals nanocomplex is limited. In this work, soymilk was used to encapsulate icariin, a well known nutraceutical with poor bioavailability. The effect of ultrasound on the quality of icariin-soymilk nanocomplexes (ISNCs) was investigated. Ultrasound could reduce the particle size, improve the surface hydrophobicity and change the microstructure of soymilk. With increasing ultrasound treatment time, an increased surface hydrophobicity was observed. The highest encapsulation efficiency (89.67 %) and loading capacity (28.92 µg/mg) were found for USI-20, whereas the smallest particle size (132.47 nm) was observed for USI-120. USI-60 showed the lowest ζ-potential (-31.33 mV) and the highest bioaccessibility (76.08 %). Ultrasound could enhance the storage stability of ISNCs. The data of NMR and fluorescence indicated that ISNCs were mainly stabilized by hydrophobic interaction.

超声波是制造纳米复合物的有效方法。豆浆是天然的纳米载体，相容性好。然而，关于豆浆-营养保健品纳米复合物的信息是有限的。在这项工作中，豆浆被用来封装淫羊藿苷，一种众所周知的生物利用度差的营养保健品。研究了超声波对淫羊藿苷-豆浆纳米复合物 (ISNCs) 质量的影响。超声波可以减小豆浆的粒径，改善表面疏水性，改变豆浆的微观结构。随着超声处理时间的增加，观察到表面疏水性增加。USI-20 的封装效率 (89.67%) 和载量 (28.92 µg/mg) 最高，而 USI-120 的粒径最小 (132.47 nm)。USI-60 显示出最低的 ζ 电位 (-31. 33 mV) 和最高的生物可及性 (76.08 %)。超声可以提高 ISNCs 的储存稳定性。NMR 和荧光数据表明，ISNCs 主要通过疏水相互作用来稳定。