Three New Lanostanoids with Anti-HCV Effects from Abies nukiangensis,Chemistry & Biodiversity

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Three New Lanostanoids with Anti-HCV Effects from Abies nukiangensis
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2022-11-18 , DOI: 10.1002/cbdv.202200941
Yong-Li Li ₁ , Zhuo-Ni Xu ₁ , Jie Li ₁ , Shuang Liang ₂ , Min-Jie Xue ₁ , Jian-Jun Wu ₁ , Xian-Wen Yang ₃

Affiliation

Three new lanostane derivatives (1–3) and twelve known triterpenoids (4–15) were isolated from the twigs and leaves of Abies nukiangensis. The structures of the new compounds were elucidated mainly by detailed analysis of their NMR and HR-ESI-MS spectroscopic data. Evaluation of the anti-HCV effects of all isolates showed that 3 exhibited moderate effect with the EC₅₀ value of 11.09 μM.

中文翻译：

努江冷杉中三种具有抗 HCV 作用的新羊毛甾醇

从努江冷杉的枝叶中分离出三种新的羊毛甾烷衍生物 ( 1-3 )和十二种已知的三萜类化合物( 4-15 )。主要通过详细分析其 NMR 和 HR-ESI-MS 光谱数据来阐明新化合物的结构。对所有分离物的抗HCV作用的评估表明，3表现出中度作用，EC ₅₀值为11.09 μM。

更新日期：2022-11-18

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