Abstract

The dried flower buds of Magnolia biondii Pamp (herbal name, Xin-Yi) are a traditional Chinese medicine with a long history of clinical use in the treatment of allergic rhinitis and sinusitis. However, the constituents responsible for its antiallergic effects remain clearly unidentified. In the present study, totally 33 lignans were obtained from M. biondii. Among them, two novel furofuran lignans (1 and 2), two novel tetrahydrofuran lignans (3 and 4), and other 16 known lignans were isolated first time from M. biondii. The antiallergic effects of compounds 1-33 on mouse bone marrow-derived mast cells (BMMCs) degrunaliton were evaluated and results showed that compounds 7, 8, 13, 15 and 18 could significantly inhibited β-hex release on BMMCs. The results proved that furofuran and tetrahydrofuran lignans were the main constituents in M. biondii and their antiallergic effects were related with suppressing mast cell activation.

摘要

厚朴（辛夷）的干燥花蕾是一种临床使用历史悠久的传统中药，用于治疗过敏性鼻炎和鼻窦炎。然而，其抗过敏作用的成分仍不清楚。本研究共从M. biondii中分离得到33 种木脂素。其中，两种新型呋喃呋喃木脂素( 1和2 )、两种新型四氢呋喃木脂素( 3和4 )以及其他16种已知木脂素是首次从M. biondii中分离得到。评价了化合物1-33对小鼠骨髓源性肥大细胞(BMMCs)去核化的抗过敏作用，结果表明化合物7、8、13、15和18能显着抑制BMMCs上β - hex的释放。结果证明，呋喃呋喃和四氢呋喃木脂素是M. biondii中的主要成分，其抗过敏作用与抑制肥大细胞活化有关。