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Mitochondria and peroxisomes are NIXed for clearance
The EMBO Journal ( IF 9.4 ) Pub Date : 2022-11-17 , DOI: 10.15252/embj.2022112918
Chunxin Wang 1 , Richard Youle 1
Affiliation  

A recent report shows that the iron chelator DFP induces both mitophagy and pexophagy in a BNIP3/NIX-dependent manner. Previously known as a mitophagy receptor, NIX was also independently localized to peroxisomes to promote pexophagy in several physiological conditions, illustrating the significance of this novel function.

中文翻译:

线粒体和过氧化物酶体被混合以进行清除

最近的一份报告表明,铁螯合剂 DFP 以 BNIP3/NIX 依赖性方式诱导线粒体自噬和 pexophagy。NIX 以前被称为线粒体自噬受体,它也独立定位于过氧化物酶体,在多种生理条件下促进 pexophagy,说明了这种新功能的重要性。
更新日期:2022-11-17
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