An increasing number of studies have reported that microbiome can affect drug response by altering pharmacokinetics and pharmacodynamics of formation of toxic metabolites. With the development of metagenomic sequencing, gut microbial composition as well as the metabolic function are drawing more and more attention for the patient stratification. The established microbiota databases provide useful information about the gut microbe-drug interactions. However, these databases generally lacked the detailed effects on substance and the metabolites, which are helpful in elucidating the mechanisms underlying drug biotransformation and personalized medicine. To address these issues, in this study, we developed Metabolic action of gut Microbiota to Drugs (MagMD), a database and a web-service covering 32, 678 records of interactions between 2,146 gut microbes, 36 enzymes and 219 substrates (mainly drugs). The detailed annotations for each entry, including the taxonomic level of microbes, the molecular form and PubChem ID of drugs from PubChem Compound Database, types of microbial secreted enzymes and the original reference links can also be accessed from the web service.

Availability and implementation: MagMD is a publicly available resource, constantly updated. It has an intuitive web interface and can be freely accessed at http://www.unimd.org/magmd.

越来越多的研究表明，微生物组可以通过改变有毒代谢物形成的药代动力学和药效学来影响药物反应。随着宏基因组测序的发展，肠道微生物组成以及代谢功能越来越受到患者分层的关注。已建立的微生物群数据库提供了有关肠道微生物-药物相互作用的有用信息。然而，这些数据库普遍缺乏对物质和代谢物的详细影响，这有助于阐明药物生物转化和个性化医疗的潜在机制。为了解决这些问题，在这项研究中，我们开发了肠道微生物群对药物的代谢作用 (MagMD)、一个数据库和一个网络服务，涵盖 32、678 条 2、146 种肠道微生物、36 种酶和 219 种底物（主要是药物）。每个条目的详细注释，包括微生物的分类水平、来自 PubChem 化合物数据库的药物的分子形式和 PubChem ID、微生物分泌酶的类型和原始参考链接也可以从 Web 服务访问。

可用性和实施​​： MagMD 是一个公开可用的资源，不断更新。它具有直观的 Web 界面，可以在 http://www.unimd.org/magmd 上免费访问。