Abstract

W. tinctoria, an Indian herb Indrajao, has significant therapeutic potential. While studies have highlighted the anti-inflammatory potential of the leaves and bark of this plant, similar efficacy of the seed-pods remains unexplored. We demonstrate significant anti-inflammatory effects of the hexane fraction (Fr-B) of ethyl acetate extract of the seedpods in reducing lipopolysaccharide and palmitate mediated inflammation in RAW264.7 macrophages and HepG2 cells. GC-MS and NMR profiling of Fr-B revealed the existence of hexadecanoic acid, ethyl hexadecanoate, 9,12-octadecanoic acid, 9,12,15-octadecatrienoic acid, 9,12,15-octadecatrienoic acid ethyl ester, ethyl linoleate and octadecanoic acid ethyl esters.

摘要

W.tinctoria是一种印度草药Indrajao，具有显着的治疗潜力。虽然研究强调了这种植物的叶子和树皮的抗炎潜力，但种荚的类似功效仍未得到探索。我们证明了籽荚乙酸乙酯提取物的己烷组分 (Fr-B) 在减少 RAW264.7 巨噬细胞和 HepG2 细胞中脂多糖和棕榈酸酯介导的炎症方面具有显着的抗炎作用。Fr-B 的 GC-MS 和 NMR 分析表明存在十六烷酸、十六烷酸乙酯、9,12-十八烷酸、9,12,15-十八碳三烯酸、9,12,15-十八碳三烯酸乙酯、亚油酸乙酯和十八烷酸乙酯。