Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome,Environmental Science & Technology

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Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2022-11-17 , DOI: 10.1021/acs.est.2c03185
Kelsey N Thompson _{1,

2,

3} , Youssef Oulhote _{4,

5} , Pal Weihe ₆ , Jeremy E Wilkinson _{1,

3} , Siyuan Ma _{1,

2,

3} , Huanzi Zhong ₇ , Junhua Li ₇ , Karsten Kristiansen _{7,

8,

9} , Curtis Huttenhower _{1,

2,

3,

10} , Philippe Grandjean _{5,

11}

Affiliation

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts 02115, United States.
Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Harvard Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, United States.
Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts at Amherst, Amherst, Massachusetts 01003, United States.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts 02115, United States.
University of the Faroe Islands, Tórshavn 100, Faroe Islands.
Institute of Metagenomics, BGI-Shenzhen, Shenzhen 518083, China.
Department of Biology, University of Copenhagen, 2200 København, Denmark.
Institute of Metagenomics, Qingdao-Europe Advanced Institute for Life Sciences, Qingdao 266426, China.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, United States.
Department of Public Health, University of Southern Denmark, DK-5230 Odense M, Denmark.

Emerging experimental evidence indicates that toxicant-induced alterations in gut microbiota composition and activity may affect host homeostasis. However, data from human studies are scarce; to our knowledge, no previous studies have quantified the association of lifetime exposure to environmental chemicals, across multiple time points, with the composition of the adult gut microbiome. Here we studied 124 individuals born in the Faroe Islands in 1986–1987 who were followed approximately every seven years from birth through age 28 years. Organochlorine compounds, including polychlorinated biphenyls (PCBs) and pesticides, perfluoroalkyl substances (PFAS), and mercury (Hg), were measured in cord blood and longitudinally in participants’ blood. At age 28, the gut microbiome was assessed using shotgun metagenomic sequencing. Historical contaminant exposures had little direct effect on the adult gut microbiome, while a small number of fastidious anaerobes were weakly linked to recent PFAS/PFOS exposures at age 28. In this cohort, our findings suggest no lasting effects of early life exposures on adult gut microbial composition, but proximal exposures may contribute to gut microbiome alterations. The methods developed and used for this investigation may help in future identification of small but lasting impacts of environmental toxicant exposure on the gut microbiome.

中文翻译：

终生暴露于环境污染物对成人肠道微生物组的影响

新出现的实验证据表明，毒物引起的肠道微生物群组成和活性的改变可能会影响宿主体内平衡。然而，人类研究的数据很少；据我们所知，之前没有研究量化过多个时间点的终生暴露于环境化学物质与成人肠道微生物组组成之间的关联。在这里，我们研究了 124 名 1986 年至 1987 年出生于法罗群岛的人，他们从出生到 28 岁大约每七年接受一次跟踪调查。在脐带血和参与者血液中纵向测量有机氯化合物，包括多氯联苯 (PCB) 和杀虫剂、全氟烷基物质 (PFAS) 和汞 (Hg)。在 28 岁时，使用鸟枪法宏基因组测序评估了肠道微生物组。历史污染物暴露对成人肠道微生物组几乎没有直接影响，而少数苛刻的厌氧菌与 28 岁时最近的 PFAS/PFOS 暴露弱相关。在这个队列中，我们的研究结果表明，早期生命暴露对成人肠道没有持久影响微生物组成，但近端暴露可能会导致肠道微生物组的改变。为这项调查开发和使用的方法可能有助于未来确定环境毒物暴露对肠道微生物群的微小但持久的影响。但近端接触可能会导致肠道微生物群的改变。为这项调查开发和使用的方法可能有助于未来确定环境毒物暴露对肠道微生物群的微小但持久的影响。但近端接触可能会导致肠道微生物群的改变。为这项调查开发和使用的方法可能有助于未来确定环境毒物暴露对肠道微生物群的微小但持久的影响。

更新日期：2022-11-17

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