Bisymmetric coherent acoustic tweezers based on modulation of surface acoustic waves for dynamic and reconfigurable cluster manipulation of particles and cells,Lab on a Chip

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Bisymmetric coherent acoustic tweezers based on modulation of surface acoustic waves for dynamic and reconfigurable cluster manipulation of particles and cells
Lab on a Chip ( IF 6.1 ) Pub Date : 2022-11-17 , DOI: 10.1039/d2lc00812b
Hemin Pan ₁ , Deqing Mei ₁ , Chengyao Xu ₂ , Shuo Han ₂ , Yancheng Wang ₁

Affiliation

Acoustic tweezers based on surface acoustic waves (SAWs) have raised great interest in the fields of tissue engineering, targeted therapy, and drug delivery. Generally, the complex structure and array layout design of interdigital electrodes would restrict the applications of acoustic tweezers. Here, we present a novel approach by using bisymmetric coherent acoustic tweezers to modulate the shape of acoustic pressure fields with high flexibility and accuracy. Experimental tests were conducted to perform the precise, contactless, and biocompatible cluster manipulation of polystyrene microparticles and yeast cells. Stripe, dot, quadratic lattice, hexagonal lattice, interleaved stripe, oblique stripe, and many other complex arrays were achieved by real-time modulation of amplitudes and phase relations of coherent SAWs to demonstrate the capability of the device for the cluster manipulation of particles and cells. Furthermore, rapid switching among various arrays, shape regulation, geometric parameter modulation of array units, and directional translation of microparticles and cells were implemented. This study demonstrated a favorable technique for flexible and versatile manipulation and patterning of cells and biomolecules, and it has the advantages of high manipulation accuracy and adjustability, thus it is expected to be utilized in the fields of targeted cellular assembly, biological 3D printing, and targeted release of drugs.

中文翻译：

基于表面声波调制的双对称相干声学镊子用于粒子和细胞的动态和可重构簇操作

基于表面声波 (SAW) 的声学镊子引起了组织工程、靶向治疗和药物输送领域的极大兴趣。通常，叉指电极复杂的结构和阵列布局设计会限制声学镊子的应用。在这里，我们提出了一种新颖的方法，即使用双对称相干声学镊子以高度灵活和准确的方式调制声压场的形状。进行了实验测试，以对聚苯乙烯微粒和酵母细胞进行精确、非接触和生物相容的簇操作。条纹、圆点、方格、六方格、交错条纹、斜条纹、和许多其他复杂的阵列是通过实时调制相干 SAW 的振幅和相位关系来实现的，以展示该设备对粒子和细胞进行集群操作的能力。此外，还实现了各种阵列之间的快速切换、形状调控、阵列单元的几何参数调制以及微粒和细胞的定向平移。该研究展示了一种对细胞和生物分子进行灵活多变的操作和图案化的有利技术，具有操作精度高和可调节性强的优点，有望应用于靶向细胞组装、生物3D打印、靶向释放药物。实现了阵列单元的形状调控、几何参数调制以及微粒和细胞的定向平移。该研究展示了一种对细胞和生物分子进行灵活多变的操作和图案化的有利技术，具有操作精度高和可调节性强的优点，有望应用于靶向细胞组装、生物3D打印、靶向释放药物。实现了阵列单元的形状调控、几何参数调制以及微粒和细胞的定向平移。该研究展示了一种对细胞和生物分子进行灵活多变的操作和图案化的有利技术，具有操作精度高和可调节性强的优点，有望应用于靶向细胞组装、生物3D打印、靶向释放药物。

更新日期：2022-11-17

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