The inherent antibiotic activity of myxobacteria-derived autofluorescent outer membrane vesicles is switched on and off by light stimulation,Nanoscale

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The inherent antibiotic activity of myxobacteria-derived autofluorescent outer membrane vesicles is switched on and off by light stimulation
Nanoscale ( IF 5.8 ) Pub Date : 2022-11-17 , DOI: 10.1039/d2nr02743g
Philipp Lapuhs _{1,

2} , Eilien Heinrich _{1,

2} , Ronald Garcia _{1,

3} , Adriely Goes _{1,

2} , Nicolas Frank _{1,

2} , Lukas Bollenbach _{1,

2} , Veronika Stibane ₁ , Thomas Kuhn _{1,

2} , Marcus Koch ₄ , Alexandra K Kiemer ₂ , Rolf Müller _{1,

2,

3} , Kathrin Fuhrmann ₁ , Gregor Fuhrmann _{1,

2,

5}

Affiliation

Outer membrane vesicles are small, lipid-based vesicles shed from the outer membrane of Gram-negative bacteria. They are becoming increasingly recognised as important factors for resistance gene transfer, bacterial virulence factors and host cell modulation. The presence of pathogenic factors and antimicrobial compounds in bacterial vesicles has been proven in recent years, but it remains unclear, if and how environmental factors, such as light specifically regulate the vesicle composition. We report the first example of autofluorescent vesicles derived from non-pathogenic soil-living myxobacteria. These vesicles additionally showed inherent antibiotic activity, a property that is specifically regulated by light stimulation of the producing bacteria. Our data provide a central basis for better understanding the environmental impact on bacteria-derived vesicles, and design of future therapeutic options.

中文翻译：

粘细菌衍生的自发荧光外膜囊泡的固有抗生素活性通过光刺激打开和关闭

外膜囊泡是从革兰氏阴性细菌的外膜脱落的基于脂质的小囊泡。它们越来越被认为是抗性基因转移、细菌毒力因子和宿主细胞调节的重要因素。近年来已证明细菌囊泡中存在致病因子和抗菌化合物，但尚不清楚环境因素（例如光）是否以及如何特异性调节囊泡组成。我们报告了第一个来自非致病性土壤生活粘细菌的自体荧光囊泡的例子。这些囊泡还显示出固有的抗生素活性，这种特性受产生细菌的光刺激的特异性调节。

更新日期：2022-11-17

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