Butyrate Attenuates Hepatic Steatosis Induced by a High-Fat and Fiber-Deficient Diet via the Hepatic GPR41/43-CaMKII/HDAC1-CREB Pathway,Molecular Nutrition & Food Research

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Butyrate Attenuates Hepatic Steatosis Induced by a High-Fat and Fiber-Deficient Diet via the Hepatic GPR41/43-CaMKII/HDAC1-CREB Pathway
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-11-16 , DOI: 10.1002/mnfr.202200597
Mingxuan Zheng ₁ , Xiaoying Yang ₁ , Qingyuan Wu ₁ , Yuying Gong ₁ , Ning Pang ₂ , Xing Ge ₁ , Nathan Nagaratnam ₃ , Pengfei Jiang ₁ , Menglu Zhou ₁ , Tao Hu ₁ , Hui Hua ₁ , Kuiyang Zheng _{1,

4} , Xu-Feng Huang ₃ , Yinghua Yu _{1,

3}

Affiliation

Hepatic steatosis is a major health issue that can be attenuated by a healthy diet. This study investigates the effects and molecular mechanisms of butyrate, a dietary fiber metabolite of gut microbiota, on lipid metabolism in hepatocytes.

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