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Comparative Study on Volatile Oils among Bupleuri radix Species and Habitats: Yields, Chemical Characterization and Antipyretic Activities
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2022-11-16 , DOI: 10.1002/cbdv.202200549 Ruoqiao Chen 1 , Xiaoshuang Wang 2 , Hongting Xu 1 , Ruizhi Zhao 2 , Qiaohong Hu 1
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2022-11-16 , DOI: 10.1002/cbdv.202200549 Ruoqiao Chen 1 , Xiaoshuang Wang 2 , Hongting Xu 1 , Ruizhi Zhao 2 , Qiaohong Hu 1
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Volatile oils from several Bupleuri radix (BR) are reported as potential sources of drugs. To provide evidence for the application of BR, the volatile oils from 19 batches of different species and habitats of BR including Bupleurum chinese DC. (BCD), Bupleurum scorzonerifolium Willd. (BSW), Bupleurum bicaule Helm (BBH), Bupleurum marginatum var. stenophyllum (Wolff) Shan et Y.Li (BMS), Bupleurum marginatum Wall.ex DC. (BMW) and Bupleurum falcatum L. (BFL) were investigated. The composition of BR volatile oils was determined by GC/MS. Samples were clustered by hierarchical cluster analysis (HCA). Fever was induced by Lipopolysaccharide (LPS), and antipyretic activities of BR volatile oils were evaluated with Chaihu injection (CI) as the positive control. The yields of volatile oils were among 360–5320 ppm. A total of 229 components were identified by GC/MS. Samples could be divided into 4 clusters by HCA. 4 representative samples, one for each cluster, were selected to further compare their antipyretic activities. For the highest content of volatile oil (5320 ppm) and the best activity, BSW has great potential for utilization.
中文翻译：
柴胡种属和生境挥发油的比较研究：产量、化学性质和解热活性
据报道，来自几种柴胡(BR) 的挥发油是潜在的药物来源。为BR的应用提供证据，包括柴胡在内的19批不同品种和生境的BR挥发油。(BCD)，柴胡。(BSW), Bupleurum bicaule Helm (BBH), Bupleurum marginatum var. stenophyllum (Wolff) Shan et Y.Li (BMS), Bupleurum marginatum Wall.ex DC。(BMW) 和柴胡L. (BFL) 进行了调查。BR 挥发油的组成由 GC/MS 测定。通过层次聚类分析 (HCA) 对样本进行聚类。以脂多糖（LPS）诱导发热，以柴胡注射液（CI）作为阳性对照评价BR挥发油的解热活性。挥发油的产率在360-5320 ppm之间。GC/MS 共鉴定出 229 种成分。HCA 可以将样本分为 4 个簇。选择了 4 个代表性样品，每组一个，以进一步比较它们的解热活性。BSW的挥发油含量最高（5320 ppm），活性最好，具有很大的利用潜力。
更新日期：2022-11-16
中文翻译：
柴胡种属和生境挥发油的比较研究：产量、化学性质和解热活性
据报道，来自几种柴胡(BR) 的挥发油是潜在的药物来源。为BR的应用提供证据，包括柴胡在内的19批不同品种和生境的BR挥发油。(BCD)，柴胡。(BSW), Bupleurum bicaule Helm (BBH), Bupleurum marginatum var. stenophyllum (Wolff) Shan et Y.Li (BMS), Bupleurum marginatum Wall.ex DC。(BMW) 和柴胡L. (BFL) 进行了调查。BR 挥发油的组成由 GC/MS 测定。通过层次聚类分析 (HCA) 对样本进行聚类。以脂多糖（LPS）诱导发热，以柴胡注射液（CI）作为阳性对照评价BR挥发油的解热活性。挥发油的产率在360-5320 ppm之间。GC/MS 共鉴定出 229 种成分。HCA 可以将样本分为 4 个簇。选择了 4 个代表性样品，每组一个，以进一步比较它们的解热活性。BSW的挥发油含量最高（5320 ppm），活性最好，具有很大的利用潜力。
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