Electromembrane extraction (EME), despite its high performance in the extraction of highly polar basic analytes, has challenges in extracting polar acidic compounds. This is the result of a lack of access to the suitable supported liquid membrane (SLM) for this group of analytes. Therefore, it would be valuable to provide a suitable solution for this problem. Accordingly, in the present study, a new method based on on-chip EME followed by HPLC with UV detection was developed for the extraction and determination of some polar acidic drugs in order to provide high extraction efficiency. Here, a new polymeric sheet was introduced as a support for SLM immobilization, which is not only used to impregnate 1-octanol as SLM but also enhances extraction recovery by exerting effective interactions with target acidic analytes. The polymeric sheet was composed of nanofibers prepared by electrospinning polycaprolactone blended with a composite of graphene oxide and aluminum polycations. Encapsulation of the composite in polycaprolactone nanofibers improved the extraction efficiency of polar acidic compounds by creating additional interactions with the target analytes, including hydrogen bonding, dipole-dipole, π-π stacking, and anion exchange process. The electrospun nanofiber-based sheet was characterized by FE-SEM, EDX, elemental mapping, TEM, and AFM. The extraction parameters were further optimized with an orthogonal-rotatable central composite design (CCD). Applying CCD determined optimal conditions by minimum experiments, and interactions between the parameters were clarified. Under optimized conditions, the proposed method provided extraction recoveries from 36.5 to 64.1%, relative standard deviations less than 5.7% (n = 4), and detection limits of 0.3–0.5 μg L⁻¹. Furthermore, the proposed method was successfully used for the determination of target analytes in plasma samples, providing good accuracy (88–110%) and precision (2.3–8.8%).

电膜萃取 (EME) 尽管在萃取强极性碱性分析物方面表现出色，但在萃取极性酸性化合物方面存在挑战。这是由于无法获得适合这组分析物的支持液膜 (SLM) 的结果。因此，为该问题提供合适的解决方案将很有价值。因此，在本研究中，开发了一种基于片上 EME 随后采用带紫外检测的 HPLC 的新方法，用于提取和测定某些极性酸性药物，以提供高提取效率。在这里，引入了一种新的聚合物片作为 SLM 固定的支持，它不仅用于浸渍 1-辛醇作为 SLM，还通过与目标酸性分析物发挥有效相互作用来提高提取回收率。聚合物片由纳米纤维组成，该纳米纤维通过静电纺丝聚己内酯与氧化石墨烯和铝聚阳离子的复合物混合制备。将复合材料包封在聚己内酯纳米纤维中，通过与目标分析物产生额外的相互作用（包括氢键、偶极-偶极、π-π 堆积和阴离子交换过程），提高了极性酸性化合物的提取效率。基于电纺纳米纤维的片材通过 FE-SEM、EDX、元素映射、TEM 和 AFM 进行了表征。使用正交旋转中心复合设计 (CCD) 进一步优化提取参数。应用 CCD 通过最少的实验确定最佳条件，并阐明参数之间的相互作用。在优化条件下，所提出的方法提供了 36 的提取回收率。^-1。此外，所提出的方法已成功用于测定血浆样品中的目标分析物，具有良好的准确度 (88–110%) 和精密度 (2.3–8.8%)。