Designable microfluidic ladder networks from backstepping microflow analysis for mass production of monodisperse microdroplets,Lab on a Chip

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Designable microfluidic ladder networks from backstepping microflow analysis for mass production of monodisperse microdroplets
Lab on a Chip ( IF 6.1 ) Pub Date : 2022-11-15 , DOI: 10.1039/d2lc00771a
Chuan-Fu Deng ₁ , Yao-Yao Su ₁ , Shi-Hao Yang ₁ , Qing-Rong Jiang ₁ , Rui Xie _{1,

2} , Xiao-Jie Ju _{1,

2} , Zhuang Liu _{1,

2} , Da-Wei Pan _{1,

2} , Wei Wang _{1,

2} , Liang-Yin Chu _{1,

2}

Affiliation

Controllable mass production of monodisperse droplets plays a key role in numerous fields ranging from scientific research to industrial application. Microfluidic ladder networks show great potential in mass production of monodisperse droplets, but their design with uniform microflow distribution remains challenging due to the lack of a rational design strategy. Here an effective design strategy based on backstepping microflow analysis (BMA) is proposed for the rational development of microfluidic ladder networks for mass production of controllable monodisperse microdroplets. The performance of our BMA rule for rational microfluidic ladder network design is demonstrated by using an existing analogism-derived rule that is widely used for the design of microfluidic ladder networks as the control group. The microfluidic ladder network designed by the BMA rule shows a more uniform flow distribution in each branch microchannel than that designed by the existing rule, as confirmed by single-phase flow simulation. Meanwhile, the microfluidic ladder network designed by the BMA rule allows mass production of droplets with higher size monodispersity in a wider window of flow rates and mass production of polymeric microspheres from such highly monodisperse droplet templates. The proposed BMA rule provides new insights into the microflow distribution behaviors in microfluidic ladder networks based on backstepping microflow analysis and provides a rational guideline for the efficient development of microfluidic ladder networks with uniform flow distribution for mass production of highly monodisperse droplets. Moreover, the BMA method provides a general analysis strategy for microfluidic networks with parallel multiple microchannels for rational scale-up.

中文翻译：

用于单分散微滴批量生产的反步微流分析的可设计微流体阶梯网络

单分散液滴的可控大规模生产在从科学研究到工业应用的众多领域中起着关键作用。微流控梯形网络在大规模生产单分散液滴方面显示出巨大潜力，但由于缺乏合理的设计策略，其具有均匀微流分布的设计仍然具有挑战性。这里提出了一种基于反推微流分析 (BMA) 的有效设计策略，用于合理开发用于大规模生产可控单分散微滴的微流体阶梯网络。通过使用广泛用于微流体阶梯网络设计的现有类比派生规则作为对照组，证明了我们用于合理微流体阶梯网络设计的 BMA 规则的性能。BMA 规则设计的微流控梯形网络在每个分支微通道中的流量分布比现有规则设计的更均匀，单相流模拟证实了这一点。同时，由 BMA 规则设计的微流体梯形网络允许在更宽的流速窗口中大量生产具有更高尺寸单分散性的液滴，并从这种高度单分散的液滴模板中大量生产聚合物微球。所提出的 BMA 规则为基于反步微流分析的微流控梯形网络中的微流分布行为提供了新的见解，并为高效开发具有均匀流量分布的微流控梯形网络以用于高度单分散液滴的大规模生产提供了合理的指导。而且，

更新日期：2022-11-15

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