Bifidobacterium breve CCFM1078 Alleviates Collagen-Induced Arthritis in Rats via Modulating the Gut Microbiota and Repairing the Intestinal Barrier Damage,Journal of Agricultural and Food Chemistry

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Bifidobacterium breve CCFM1078 Alleviates Collagen-Induced Arthritis in Rats via Modulating the Gut Microbiota and Repairing the Intestinal Barrier Damage
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2022-11-15 , DOI: 10.1021/acs.jafc.2c04602
Bowen Li _{1,

2} , Mengfan Ding _{1,

2} , Xiaoming Liu _{1,

2,

3} , Jianxin Zhao _{1,

2,

3} , R Paul Ross _{3,

4} , Catherine Stanton _{3,

4,

5} , Bo Yang _{1,

2,

3} , Wei Chen _{1,

2,

6,

7}

Affiliation

This study focused on the effects of Bifidobacterium breve CCFM1078 on the intestinal barrier and systemic inflammation of collagen-induced arthritis (CIA) rats. Female rats were divided into three groups with daily intragastric administration of either saline (control group and model group) or B. breve CCFM1078 (CCFM1078 group, 3 × 10⁹cfu/rat per day) for 5 weeks. In the Model and CCFM1078 groups, arthritis was induced by subcutaneous collagen injection. We found that B. breve CCFM1078 can repair the intestinal barrier, reduce LPS translocation, regulate gut microbiota composition, and increase short-chain fatty acids in the intestine. Then, it can reduce pro-inflammatory cytokines release, adjust immune dysfunction, and inhibit TLR4-MyD88-dependent pathways and downstream inflammatory pathways to alleviate joint inflammation in CIA rats. These findings suggest that B. breve CCFM1078 may alleviate joint inflammation by adjusting the profile of gut microbiota and enhancing the intestinal barrier.

中文翻译：

短双歧杆菌 CCFM1078 通过调节肠道菌群和修复肠道屏障损伤减轻胶原诱导的大鼠关节炎

本研究的重点是短双歧杆菌CCFM1078 对胶原性关节炎 (CIA) 大鼠的肠道屏障和全身炎症的影响。雌性大鼠分为三组，每日灌胃生理盐水（对照组和模型组）或短双歧杆菌 CCFM1078（CCFM1078 组，每天 3 × 10 ⁹ cfu/大鼠），持续 5 周。在模型和 CCFM1078 组中，通过皮下注射胶原蛋白诱导关节炎。我们发现B. breveCCFM1078 可以修复肠道屏障，减少 LPS 转运，调节肠道菌群组成，增加肠道内的短链脂肪酸。然后，它可以减少促炎细胞因子的释放，调节免疫功能障碍，抑制 TLR4-MyD88 依赖通路和下游炎症通路，从而减轻 CIA 大鼠的关节炎症。这些发现表明，短双歧杆菌 CCFM1078 可以通过调整肠道微生物群的分布和增强肠道屏障来减轻关节炎症。

更新日期：2022-11-15

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